integralmolecular中国总代理

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LIPOPARTICLETECHNOLOGY

Application Notes

THE LIPOPARTICLELipoparticles incorporate high concentrations of properly folded and oriented membrane proteins on their surface. GPCRs, ion channels, and other complex membrane proteins can be incorporated into Lipoparticles at concentrations of 50-200 pmol/mg, 10-100 fold greater than cells or membrane preparations. Because Lipoparticles are virus-like particles （VLPs） based on the natural retroviral budding process, they are uniform in diameter （~150 nm） and maintain the orientation of incorporated membrane proteins. Integral Molecular produces, purifies, and delivers custom Lipoparticles containing user specified membrane proteins for applications in antibody development and drug discovery.

MODIFIED LIPOPARTICLESIntegral Molecular offers biochemically modified Lipoparticles containing biotin tags and fluorophores to enable membrane proteins to be captured onto solid supports and visualized without disrupting the conformation of incorporated receptor targets. Modified Lipoparticles are suited for use in specialized antibody development applications including:

ADVANTAGESLipoparticles offer distinct advantages over traditional sources of membrane proteins such as whole cells or membrane preparations:

Incorporation of difficult membrane proteinsLipoparticles can incorporate oligomeric and multispanning membrane proteins in their correct topology. Receptors that are toxic or poorly trafficked can also be incorporated into Lipoparticles.High purity and high concentrations of membrane proteinsLipoparticles provide a source of concentrated membrane proteins that are free of cytoplasmic proteins and misoriented proteins, improving assay sensitivity and the specificity of immune responses.Convenient and consistent source of membrane proteinsLipoparticles maintain membrane proteins in their native lipid environment, preserving protein conformation. Lipoparticles are shipped ready to use and are stable for months with refrigeration, thereby eliminating end-user preparation steps and reducing experimental variability.

LIPOPARTICLE STRUCTUREThe Lipoparticle structure is based on membrane-enveloped retroviruses. Non-infectious, retroviral virus-like particles （VLPs） are produced when the viral protein 'Gag' buds through the host cell membrane. The Gag protein forms a core which becomes enwrapped by the cellmembrane. Once the membrane ‘pinches’ off, newly formed Lipoparticles diffuse away from the cell, carrying target membrane proteins with it. Since the lipid membrane surrounding the Lipoparticle is derived directly from the host cell membrane, the incorporated receptors remain correctly oriented in a native lipid environment. Lipoparticles contain no viral genome or Envelope protein, and are replication incompetent and non-infectious, rendering them safe to manipulate in a standard laboratory environment.

LIPOPARTICLE QUALITY CONTROLAt Integral Molecular, Lipoparticles undergo rigorous quality control before they are shipped. As a result, the Lipoparticles you receive are highly purified, homogeneous, and stable for nths to years. Maintaining

• Immunization
• Phage and yeast display
• Screening for and characterizing MAbs
• Ligand binding assays
• Probing cells and microarrays
• Biosensor binding kinetics

Application versatilityLipoparticles can be used with conventional formats such as microplates and beads, but their small size, exceptional purity, and stability also make them amenable to formats that are otherwise difficult for membrane proteins, such as microfluidics, microarrays, and biosensors.

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2：货品全，现经营过700多个品牌，基本所有生物试剂耗材都可以进口，特别是冷偏的产品那就更有优势，

3：提供加急服务，一般1-2周到货，超过时限加急费全免

4：价格公道，绝大部分价格有优势，当然不能保证100%产品都是,因为意味着没有服务.

5：良好的信誉，大部分客户我们提供货到付款服务，客户包括清华，北大交大复旦，中山等100多所大学，ROCHE，阿斯利康，国药，fisher等500多家公司

6：我们还是Santa,Advanced Biotechnologies Inc, Integralmolecular,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. FormuMax Scientific,Inc, GePromegaridege, Glycotope Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,Integralmolecular, Polysciences,prospecbi, QA-BIO,quickzyme,FULLERLABS,INC,sterlitech；sysy,TriLink BioTechnologies,Inc；worthington-biochem,zyagen等几十家国外公司授权代理。7：我们还是invitrogen,qiagen,Integralmolecularam,sigma;Promega,roche,merck, rnd,BD, GE,pierce,BioLegend等*批发，欢迎合作。

上海金山科研平台实验试剂有限公司：杨建辉400：办公：*8006企业: :http://www.qfbio.com/地址：上海市浦东新区晨阳路225弄东方现代商业广场46号303室(近东亭路)