货号：MABT109

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Aggrecan Antibody, clone 7D1 | MABT109 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~60 kDa observed. Uniprot describes two isoforms at ~225 kDa and ~221 kDa. Aggrecan is degraded by aggrecanase into a ~60 kDa protein and other higher molecular weight products (Lemons, M. L. et al. (2001). J Neurosci. 21(13):4772-4781. Forsang, A. J. et al. (1995). Biochem J. 310(Pt 1):337-343.). View All» Immunogen: Other corresponding to A1D1-OH of rat chondrosarcoma aggrecan. View All» Clone: 7-D-1 View All» Isotype: IgMκ View All» Background Information: Aggrecan (CSPG1, CSPCP, or CSPGCP) is a chondroitin-sulfate proteoglycan belonging to the family of letican proteins. Aggrecan is a large globar structure containing multiple domains including carbohydrate-recognition domains; complement binding protein domains; immunoglobulin domains; proteoglycan tandem repeats; and in some cases, EGF-like domains. It can be degraded by aggrecanase. The N-terminus of aggrecan binds ECM hyaluronan in the presence of the linking protein, and forms complex aggregates, whereas the C-terminus binds a number of other ECM proteins including tenascins, glycolipids, and fibulins. Aggrecan is a major component of cartilage tissue and it enables this tissue to withstand compression by maintaining the viso-elastic properties of cartilage. Aggrecan may also facilitate neural maturation and plasticity by contributing to the formation of perineuronal nets in the developing CNS. View All» Species Reactivity: Bovine View All» Species Reactivity Note: Demonstrated to react with Bovine. View All» Control: A1D1 purified protein from bovine tissue lysate. View All» Quality Assurance: Evaluated by Western blot in A1D1 purified protein from bovine tissue lysate.Western Blot Analysis: A 1:500 dilution from a representative lot detected A1D1 purified protein from bovine tissue lysate. View All» Purification Method: Purified by ion-exchange chromatography View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P07897 View All» Entrez Gene Number: NP_071526 View All» Gene Symbol:

• Acan

• Agc

• Agc1
  View All» Alternate Names:
  • Aggrecan core protein

  • Cartilage-specific proteoglycan core protein

  • CSPCP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: An extracellular matrix proteoglycan; cleaved by ADAMTS1. View All» UniProt Summary: FUNCTION: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.SUBUNIT STRUCTURE: Interacts with FBLN1 and COMP.SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.DOMAIN: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.POST-TRANSLATIONAL MODIFICATION: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides.SEQUENCE SIMILARITIES: Belongs to the aggrecan/versican proteoglycan family. Contains 1 C-type lectin domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 4 Link domains. Contains 1 Sushi (CCP/SCR) domain. View All» Product Name: Anti-Aggrecan, clone 7D1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Target / Localization: Initiation of chondrogenesis View All» Format: Purified View All» Host: Mouse View All»
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