糖基修饰的核苷酸

糖基修饰的核苷

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糖基修饰的核苷酸（糖基修饰 DNA/RNA）

核苷类药物由于具有良好的抗病毒和抗肿瘤作用而在临床上被广泛应用,近年来随着合成方法和药学研究手段的进步,大量新型核苷化合物被制备并用于抗病毒和抗肿瘤的研究,如替比夫定（bivudine,L-dt）在2006年被FDA批准用于乙型肝炎的治疗。但对一些致病率高的病毒感染如乙型肝炎,和恶性肿瘤现有药物尚不能*解决问题,而且临床治疗中耐药性问题日益突出,严重地阻碍了此类药物的发展。因此寻找高效低毒的抗病毒和抗肿瘤核苷药物一直是人们研究的热点。 核苷类化合物的抗病毒和抗肿瘤作用机制大都是由于具有与天然核苷类似的结构,掺入病毒或肿瘤细胞的DNA链中,干扰其DNA和蛋白质的生物合成而起到抗病毒和抗肿瘤作用的。 核苷类化合物的修饰改造部位包括糖基和碱基部分,其中大部分为糖基修饰改造的产物。糖基改造修饰的类型包括无环核苷,脱氧核苷,杂原子引入,构型变化,糖环大小的变化等。

TriLink公司的糖基修饰的核苷列表：

N-1015-1

2'-O-Methyladenosine-5'-TP

1umole

467.5

N-1015-10

2'-O-Methyladenosine-5'-TP

10umoles

3485

N-1015-5

2'-O-Methyladenosine-5'-TP

5umoles

1955

N-1016-1

2'-O-Methylcytidine-5'-TP

1umole

467.5

N-1016-10

2'-O-Methylcytidine-5'-TP

10umoles

3485

N-1016-5

2'-O-Methylcytidine-5'-TP

5umoles

1955

N-1017-1

2'-O-Methylguanosine-5'-TP

1umole

467.5

N-1017-10

2'-O-Methylguanosine-5'-TP

10umoles

3485

N-1017-5

2'-O-Methylguanosine-5'-TP

5umoles

1955

N-1018-1

2'-O-Methyluridine-5'-TP

1umole

467.5

N-1018-10

2'-O-Methyluridine-5'-TP

10umoles

3485

N-1018-5

2'-O-Methyluridine-5'-TP

5umoles

1955

N-1021-1

2'-O-Methylinosine-5'-Triphosphate

1umole

1317.5

N-1021-10

2'-O-Methylinosine-5'-Triphosphate

10umoles

10625

N-1021-5

2'-O-Methylinosine-5'-Triphosphate

5umoles

6205

N-1026-1

2'-Amino-2'-deoxycytidine-5'-TP

1umole

1317.5

N-1026-10

2'-Amino-2'-deoxycytidine-5'-TP

10umoles

10625

N-1026-5

2'-Amino-2'-deoxycytidine-5'-TP

5umoles

6205

N-1027-1

2'-Amino-2'-deoxyuridine-5'-TP

1umole

1317.5

N-1027-10

2'-Amino-2'-deoxyuridine-5'-TP

10umoles

10625

N-1027-5

2'-Amino-2'-deoxyuridine-5'-TP

5umoles

6205

N-1028-1

2'-Azido-2'-deoxycytidine-5'-TP

1umole

1317.5

N-1028-10

2'-Azido-2'-deoxycytidine-5'-TP

10umoles

10625

N-1028-5

2'-Azido-2'-deoxycytidine-5'-TP

5umoles

6205

N-1029-1

2'-Azido-2'-deoxyuridine-5'-TP

1umole

1317.5

N-1029-10

2'-Azido-2'-deoxyuridine-5'-TP

10umoles

10625

N-1029-5

2'-Azido-2'-deoxyuridine-5'-TP

5umoles

6205

N-1033-1

Aracytidine-5'-Triphosphate

1umole

892.5

N-1033-10

Aracytidine-5'-Triphosphate

10umoles

7055

N-1033-5

Aracytidine-5'-Triphosphate

5umoles

4335

N-1034-1

Arauridine-5'-Triphosphate

1umole

1657.5

N-1034-10

Arauridine-5'-Triphosphate

10umoles

14450

N-1034-5

Arauridine-5'-Triphosphate

5umoles

7905

N-1040-1

2'-O-Methyl-2-aminoadenosine-5'-TP

1umole

1317.5

N-1040-10

2'-O-Methyl-2-aminoadenosine-5'-TP

10umoles

10625

N-1040-5

2'-O-Methyl-2-aminoadenosine-5'-TP

5umoles

6205

N-1041-1

2'-O-Methylpseudouridine-5'-TP

1umole

892.5

N-1041-10

2'-O-Methylpseudouridine-5'-TP

10umoles

7055

N-1041-5

2'-O-Methylpseudouridine-5'-TP

5umoles

4335

N-1043-1

2'-O-Methyl-5-methyluridine-5'-TP

1umole

892.5

N-1043-10

2'-O-Methyl-5-methyluridine-5'-TP

10umoles

7055

N-1043-5

2'-O-Methyl-5-methyluridine-5'-TP

5umoles

4335

N-1045-1

2'-Azido-2'-deoxyadenosine-5'-TP

1umole

1317.5

N-1045-10

2'-Azido-2'-deoxyadenosine-5'-TP

10umoles

10625

N-1045-5

2'-Azido-2'-deoxyadenosine-5'-TP

5umoles

6205

N-1046-1

2'-Amino-2'-deoxyadenosine-5'-TP

1umole

892.5

N-1046-10

2'-Amino-2'-deoxyadenosine-5'-TP

10umoles

7055

N-1046-5

2'-Amino-2'-deoxyadenosine-5'-TP

5umoles

4335

N-1048-1

Araadenosine-5'-TP

1umole

1317.5

N-1048-10

Araadenosine-5'-TP

10umoles

10625

N-1048-5

Araadenosine-5'-TP

5umoles

6205

N-1056-1

3'-O-Methyladenosine-5'-TP

1umole

1317.5

N-1056-10

3'-O-Methyladenosine-5'-TP

10umoles

10625

N-1056-5

3'-O-Methyladenosine-5'-TP

5umoles

6205

N-1057-1

3'-O-Methylcytidine-5'-TP

1umole

1317.5

N-1057-10

3'-O-Methylcytidine-5'-TP

10umoles

10625

N-1057-5

3'-O-Methylcytidine-5'-TP

5umoles

6205

N-1058-1

3'-O-Methylguanosine-5'-TP

1umole

1317.5

N-1058-10

3'-O-Methylguanosine-5'-TP

10umoles

10625

N-1058-5

3'-O-Methylguanosine-5'-TP

5umoles

6205

N-1059-1

3'-O-Methyluridine-5'-TP

1umole

1317.5

N-1059-10

3'-O-Methyluridine-5'-TP

10umoles

10625

N-1059-5

3'-O-Methyluridine-5'-TP

5umoles

6205

N-1063-1

2'-Azido-2'-deoxyguanosine-5'-TP

1umole

1317.5

N-1063-10

2'-Azido-2'-deoxyguanosine-5'-TP

10umoles

10625

N-1063-5

2'-Azido-2'-deoxyguanosine-5'-TP

5umoles

6205

N-2053-1

2'-Deoxy-L-adenosine-5'-TP

1umoles

　

N-2053-10

2'-Deoxy-L-adenosine-5'-TP

10umoles

14450

N-2053-5

2'-Deoxy-L-adenosine-5'-TP

5umoles

7905

N-2054-1

2'-Deoxy-L-cytidine-5'-TP

1umole

1657.5

N-2054-10

2'-Deoxy-L-cytidine-5'-TP

10umoles

14450

N-2054-5

2'-Deoxy-L-cytidine-5'-TP

5umoles

7905

N-2055-1

2'-Deoxy-L-guanosine-5'-TP

1umole

2975

N-2055-10

2'-Deoxy-L-guanosine-5'-TP

10umoles

24650

N-2055-5

2'-Deoxy-L-guanosine-5'-TP

5umoles

13175

N-2056-1

2'-Deoxy-L-thymidine-5'-TP

1umole

1657.5

N-2056-10

2'-Deoxy-L-thymidine-5'-TP

10umoles

14450

N-2056-5

2'-Deoxy-L-thymidine-5'-TP

5umoles

7905

N-3001-1

3'-Deoxyadenosine-5'-Triphosphate

1umole

1317.5

N-3001-10

3'-Deoxyadenosine-5'-Triphosphate

10umoles

10625

N-3001-5

3'-Deoxyadenosine-5'-Triphosphate

5umoles

6205

N-3002-1

3'-Deoxyguanosine-5'-Triphosphate

1umole

1317.5

N-3002-10

3'-Deoxyguanosine-5'-Triphosphate

10umoles

10625

N-3002-5

3'-Deoxyguanosine-5'-Triphosphate

5umoles

6205

N-3003-1

3'-Deoxycytidine-5'-Triphosphate

1umole

1317.5

N-3003-10

3'-Deoxycytidine-5'-Triphosphate

10umoles

10625

N-3003-5

3'-Deoxycytidine-5'-Triphosphate

5umoles

6205

N-3004-1

3'-Deoxy-5-Methyluridine-5'-TP

1umole

1317.5

N-3004-10

3'-Deoxy-5-Methyluridine-5'-TP

10umoles

10625

N-3004-5

3'-Deoxy-5-Methyluridine-5'-TP

5umoles

6205

N-3005-1

3'-Deoxyuridine-5'-Triphosphate

1umole

1317.5

N-3005-10

3'-Deoxyuridine-5'-Triphosphate

10umoles

10625

N-3005-5

3'-Deoxyuridine-5'-Triphosphate

5umoles

6205

N-4001-1

2',3'-Dideoxyadenosine-5'-TP

1umole

467.5

N-4001-10

2',3'-Dideoxyadenosine-5'-TP

10umoles

3485

N-4001-5

2',3'-Dideoxyadenosine-5'-TP

5umoles

1955

N-4002-1

2',3'-Dideoxyguanosine-5'-TP

1umole

467.5

N-4002-10

2',3'-Dideoxyguanosine-5'-TP

10umoles

3485

N-4002-5

2',3'-Dideoxyguanosine-5'-TP

5umoles

1955

N-4003-1

2',3'-Dideoxyuridine-5'-Triphosphate

1umole

467.5

N-4003-10

2',3'-Dideoxyuridine-5'-Triphosphate

10umoles

3485

N-4003-5

2',3'-Dideoxyuridine-5'-Triphosphate

5umoles

1955

N-4004-1

2',3'-Dideoxythymidine-5'-Triphosphate

1umole

467.5

N-4004-10

2',3'-Dideoxythymidine-5'-Triphosphate

10umoles

3485

N-4004-5

2',3'-Dideoxythymidine-5'-Triphosphate

5umoles

1955

N-4005-1

2',3'-Dideoxycytidine-5'-Triphosphate

1umole

467.5

N-4005-10

2',3'-Dideoxycytidine-5'-Triphosphate

10umoles

3485

N-4005-5

2',3'-Dideoxycytidine-5'-Triphosphate

5umoles

1955

N-4007-1

3'-Azido-2',3'-dideoxyadenosine-5'-TP

1umole

1657.5

N-4007-10

3'-Azido-2',3'-dideoxyadenosine-5'-TP

10umoles

14450

N-4007-5

3'-Azido-2',3'-dideoxyadenosine-5'-TP

5umoles

7905

N-4008-1

3'-Azido-2',3'-dideoxyguanosine-5'-TP

1umole

1657.5

N-4008-10

3'-Azido-2',3'-dideoxyguanosine-5'-TP

10umoles

14450

N-4008-5

3'-Azido-2',3'-dideoxyguanosine-5'-TP

5umoles

7905

N-4009-1

3'-Azido-2',3'-dideoxythymidine-5'-TP

1umole

1657.5

N-4009-10

3'-Azido-2',3'-dideoxythymidine-5'-TP

10umoles

14450

N-4009-5

3'-Azido-2',3'-dideoxythymidine-5'-TP

5umoles

7905

N-4010-1

3'-Amino-2',3'-dideoxyadenosine-5'-TP

1umole

2975

N-4010-10

3'-Amino-2',3'-dideoxyadenosine-5'-TP

10umoles

24650

N-4010-5

3'-Amino-2',3'-dideoxyadenosine-5'-TP

5umoles

13175

N-4011-1

3'-Amino-2',3'-dideoxycytidine-5'-TP

1umole

2975

N-4011-10

3'-Amino-2',3'-dideoxycytidine-5'-TP

10umoles

24650

N-4011-5

3'-Amino-2',3'-dideoxycytidine-5'-TP

5umoles

13175

N-4012-1

3'-Amino-2',3'-dideoxyguanosine-5'-TP

1umole

2975

N-4012-10

3'-Amino-2',3'-dideoxyguanosine-5'-TP

10umoles

24650

N-4012-5

3'-Amino-2',3'-dideoxyguanosine-5'-TP

5umoles

13175

N-4013-1

3'-Amino-2',3'-dideoxythymidine-5'-TP

1umole

1657.5

N-4013-10

3'-Amino-2',3'-dideoxythymidine-5'-TP

10umoles

14450

N-4013-5

3'-Amino-2',3'-dideoxythymidine-5'-TP

5umoles

7905

N-4014-1

3'-Azido-2',3'-dideoxycytidine-5'-TP

1umole

1657.5

N-4014-10

3'-Azido-2',3'-dideoxycytidine-5'-TP

10umoles

14450

N-4014-5

3'-Azido-2',3'-dideoxycytidine-5'-TP

5umoles

7905

N-4015-1

3'-Azido-2',3'-dideoxyuridine-5'-TP

1umole

1657.5

N-4015-10

3'-Azido-2',3'-dideoxyuridine-5'-TP

10umoles

14450

N-4015-5

3'-Azido-2',3'-dideoxyuridine-5'-TP

5umoles

7905

N-4016-1

5-Bromo-2',3'-dideoxyuridine-5'-TP

1umole

1657.5

N-4016-10

5-Bromo-2',3'-dideoxyuridine-5'-TP

10umoles

14450

N-4016-5

5-Bromo-2',3'-dideoxyuridine-5'-TP

5umoles

7905

N-4017-10

2',3'-Dideoxyinosine-5'-TP

10umoles

20995

N-4017-5

2',3'-Dideoxyinosine-5'-TP

5umoles

11815

N-9001-1

Ganciclovir-5'-Triphosphate

1umole

1317.5

N-9001-10

Ganciclovir-5'-Triphosphate

10umoles

10625