Hyaluronic Acid Oligosaccharides 透明质酸寡糖标准品

Hyaluronic Acid (HA) is a glycosaminoglycan composed of an alternating sequence of β1,3 glucuronic acid (GlcA) and β1,4 N-acetylglucosamine (GlcNAc).

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Hyaluronic Acid （HA） is a glycosaminoglycan composed of an alternating sequence of β1,3 glucuronic acid （GlcA） and β1,4 N-acetylglucosamine （GlcNAc）. In its native state HA is normally present in the extracellular matrix as a high molecular weight, high viscosity polymer essential for maintenance tissue architecture, elasticity and hydration. However it also has other key functions including the regulation of cell behaviour through specific interactions with cell surface receptors and extracellular proteins. HA binding to individual proteins commonly involves relatively short sequences in the HA polymer and there is considerable evidence that HA fragments generated in vivo have distinctive properties from the intact polymer.

Iduron offers a range of oligosaccharides produced by controlled endolyase scission of purified,low endotoxinHyaluronic Acid （Streptococcal species）. The oligosaccharides are separated by high resolution gel filtration and purity assessed on an analytical Superdex S75 HPLC column （see Data Sheets for profiles）.Size range of oligosaccharides dp2 to dp 20dp is degree of monosaccharide polyimerisation.dp2 is a disaccharide, dp4 is a tetrasaccharide etc.General formula:?HexAβ1,3 - [GlcNAcβ1,4 GlcAβ1,3]_n- GlcNAcn = number of disaccharide units

?HexA is the C4-C5 unsaturated hexuronic acid at the non-reducing end of the oligosaccharides produced by endolyase scission of the HA polymer. The C4-C5 double bond absorbs strongly at 232nm and can be used for monitoring the oligosaccharides in various separation systems.

Hyaluronic acid polymers also available covering size range from 93,000 to 1,100,000 daltons （93kDa to 1,100kDa）.

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HA02Hyaluronic Acid Oligosaccharide dp21mg2750iduronHA04Hyaluronic Acid Oligosaccharide dp41mg2750iduronHA06Hyaluronic Acid Oligosaccharide dp61mg2750iduronHA08Hyaluronic Acid Oligosaccharide dp81mg2750iduronHA10Hyaluronic Acid Oligosaccharide dp101mg2750iduronHA1100Hyaluronic Acid 1100kDa1mg3000iduronHA12Hyaluronic Acid Oligosaccharide dp121mg3250iduronHA14Hyaluronic Acid Oligosaccharide dp141mg3250iduronHA16Hyaluronic Acid Oligosaccharide dp161mg3250iduronHA18Hyaluronic Acid Oligosaccharide dp181mg3250iduronHA20Hyaluronic Acid Oligosaccharide dp201mg3250iduronHA391Hyaluronic Acid 391kDa1mg3000iduronHA804Hyaluronic Acid 804kDa1mg3000iduronHA93Hyaluronic Acid 93kDa1mg3000iduron