理想而稳定的维甲酸（ATRA）替代物

与全反式维甲酸（ATRA）不同，EC23在溶液状态下对光线、加热和空气都不敏感。EC23不溶于水，微溶于乙醇，可以DMSO配制10mg/mL母液，或者以95%乙醇配制0.33mg/mL的母液，需要漩涡助溶。后续可溶于水溶液（包括细胞培养基）。溶液形式的EC23不会降解，保存EC23溶液时不必特别注意避光密封

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理想而稳定的维甲酸（ATRA）替代物　　 添加时间：2012-1-4 14:35:48

货号：SRP001品名：合成的类维A酸EC23（4-（5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylethynyl） benzoic acid）物理特性：外观：白色粉末分子式：C₂₃H₂₄O₂分子量：332纯度：99%（HPLC）保存：合成的类维A酸EC23可以在常规实验室条件下保持化学/物理性质的稳定。可溶性：与全反式维甲酸（ATRA）不同，EC23在溶液状态下对光线、加热和空气都不敏感。EC23不溶于水，微溶于乙醇，可以DMSO配制10mg/mL母液，或者以95%乙醇配制0.33mg/mL的母液，需要漩涡助溶。后续可溶于水溶液（包括细胞培养基）。溶液形式的EC23不会降解，保存EC23溶液时不必特别注意避光密封。应用：EC23仅限科研使用，不可用于临床。实验表明，该化合物可以强力的诱导多能干细胞向神经组织方向分化，与ATRA相比，EC23能够稳定的诱导大量神经元分化。此外，EC23还能激活Hox基因转录子的表达。参考文献：

1. Christie V.B., Barnard, J.H.,] Bridgens, C.E., Batsanov, A.S., Cartmell, E.B., Collings, J.C., Maltman, D.J., Marder, T.B., Redfern, C.P.F., Whiting, A.P., Przyborski, S.A. （2008）.Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation.Organic and Biomolecular Chemistry, 6, 3497-3507.
2. Christie, V.B., Marder, T.B., Whiting, A., Przyborski, S.A. （2008）.Role of retinoids in the adult nervous system and their therapeutic potential.Mini Reviews in Medicinal Chemistry, 8, 601-608.
3. Barnard, J.H., Collings, J.C., Whiting, A., Przyborski, S.A., Marder, T.B. （2009）.Synthetic retinoids: structure-activity relationships.Chemistry, 15, 11430-52.
4. Maltman, D.J., Christie, V.B., Collings, J.C., Barnard, J.H., Fenyk, S., Marder, T.B., Whiting, A., Przyborski, S.A. （2009）.Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins.Molecular Biosystems, 5, 458-471.

品名货号规格ec23SRP0021 x 5mg clear glass vial

Differentiating neurons from stem cells just got easier.

Some retinoids can be troublesome, their lack of stability in light and susceptibility to degradation means it is impossible to know what dose you are really working with.ec23 is a synthetic retinoid whichreproduciblyinduces neuronal differentiation toconsistentlyhigh levels than those achieved with other more common retinoids.

ec23 is compley stable and the dose you add to your culture isexactlywhat you think it isevery time.

For ease of use, ec23 comes in a clear glass vial.

No more searching for your retinoid in dark glass.

ec23 is a stable, synthetic retinoid which has been shown to be a potent inducer of both pluripotent stem cell and adult neuroprogenitor cell differentiation across a range of species.^1-5

More neurons less guess work

ec23 is stable;NMR of ec23 during prolonged exposure to light demonstrates clearly ec23 remains compley intact.

1H NMR （500 MHz） spectrum （δ 7.20-8.10） of ec23 in D16-DMSO in a glass NMR tube after 3 days in the dark under air （top）, versus 3 days exposure to fluorescent light （bottom）.

Catalogue numberProduct descriptionPack sizeSRP002ec235mgDownload Reinnervate Flyer （PDF）

To order contact yourlocal LGC Standards officeor atcc@lgcstandards.comSelected publications

1.Christie V.B., et al （2008）. Organic and Biomolecular Chemistry, 6, 3497-3507.2.Blow, N. （2008）. Nature, 451, 855-858.3.Przyborski S.A. （2008）. European Pharmaceutical Review, 6, 36-39.4.Barnard, J.H., et al （2009）. Chemistry, 15, 11430-52.5.Maltman, D.J., et al （2009）. Molecular Biosystems, 5, 458-471.