金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PP2C epsilon/PPM1L Long Name: Protein Phosphatase 2C alpha Aliases: PP2CE; PPM1L Entrez Gene IDs: 151742 (Human); 242083 (Mouse); 310506 (Rat) Background: PP2C epsilon PP2C epsilon, also known as PPM1L, is a 34 kDa (predicted) widely expressed Ser/Thr phosphatase. It consists of a 25 amino acid (aa) extracellular domain, a 17 aa transmembrane segment, and a 318 aa cytoplasmic region (aa 43-360) which contains the phosphatase domain (aa 91-344). Alternate splicing generates additional isoforms of human PP2C epsilon with 179 aa or 127 aa N-terminal truncations or a 166 aa C-terminal truncation. The PP2C epsilon-mediated dephosphorylation of TAK1 and ASK1 is regulated by oxidative stress and inflammatory cytokines. Loss of PP2C epsilon function is associated with the development of metabolic syndrome.