货号：ABS44

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MAPK 1/2 Antibody | ABS44 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes MAPK1/2 at the C-terminus. View All» Molecular Weight: ~ 42, 44 kDa View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to rat MAPK 1/2 at the C-terminus. View All» Background Information: The extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), also called MAPK1 and MAPK2, are members of the Mitogen Activated Protein Kinase (MAPK) family of proteins found in all eukaryotes. Because the 44 kDa ERK1 and the 42 kDa ERK2 are highly homologous and both function in the same protein kinase cascade, the two proteins are often referred to collectively as ERK1/2 or MAPK1/2. The MAPK1/2 signaling cascade has been shown to be a critical regulator of cell differentiation, cell physiology and neuronal function. Aberrant control of MAPK1/2 activity has been implicated in a variety of pathological conditions, including cancer and autoimmune diseases, and efficient study methods are in demand. View All» Species Reactivity:

• Rat

• Mouse

• Human
  View All» Species Reactivity Note: Reacts with human, mouse, and rat. Expected to react with Bovine and Canine based on 94% sequence homology. View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a previous lot detected MAPK1/2 in BALB3T3/A31 and L6 cell lysates.Western Blot (SNAP ID) Analysis: 1-2 µg/mL from a previous lot detected MAPK1/2 in BALB3T3/A31, L6, and A431 cell lysates.Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected MAPK1/2 in NIH/3T3, A431, HeLa, and C2C12 cells. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected MAPK 1/2 on 10 µg of A431 cell lysate. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P21708 View All» Entrez Gene Number: NP_059043 View All» Gene Symbol:
  • MAPK1

  • p38

  • ERK

  • P42MAPK

  • ERK2

  • p40

  • PRKM1

  • p41mapk

  • PRKM2

  • MAPK2

  • p42-MAPK

  • p41

  • ERK-2

  • ERT1
    View All» Alternate Names:
    • Extracellular signal-regulated kinase 2

    • MAP kinase 2

    • MAPK 2

    • Mitogen-activated protein kinase 2

    • extracellular signal-regulated kinase-2

    • mitogen-activated protein kinase 1

    • protein tyrosine kinase ERK2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunocytochemistry
        View All» Entrez Gene Summary: Kinase involved in intracellular signalling; component of Mapk signalling pathway [RGD] View All» UniProt Summary: FUNCTION: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 (HSF4) By similarity.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium By similarity.ENZYME REGULATION: Activated and tyrosine phosphorylated in response to insulin and NGF.SUBUNIT STRUCTURE: Interacts with NISCH, MORG1 and HSF4 By similarity.SUBCELLULAR LOCATION: Isoform 2: Nucleus. TISSUE SPECIFICITY: Highest levels within the nervous system, expressed in different tissues, mostly in intestine, placenta and lung.DEVELOPMENTAL STAGE: Increased expression during development.DOMAIN: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM: Dually phosphorylated on Thr-203 and Tyr-205, which activates the enzyme. SEQUENCE SIMLARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-MAPK 1/2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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