金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Pax6 Long Name: Paired Box Gene 6 Entrez Gene IDs: 5080 (Human); 18508 (Mouse); 25509 (Rat) Background: Pax6 Members of the Pax family of transcription factors contain a paired box DNA binding domain and may or may not contain a paired-type homeodomain and/or octapeptide region. Nine Pax genes have been identified in mammals and are divided into four subgroups based on the sequence elements present. Pax genes play a variety of roles during embryogenesis, regulating cell-lineage specification, proliferation, migration, and survival of diverse cell and tissue types. Several of the Pax genes are also expressed in cancers and serve as tumor markers.

Pax6 is a highly conserved transcription factor essential for the development of tissues including the eyes, central nervous system, and endocrine glands of vertebrates and invertebrates. Pax6 is a key regulator that is required for normal islet development.