货号：AB4334

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NODAL Antibody | AB4334 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NODAL near the N-terminus of the mature chain. View All» Molecular Weight: ~42 kDa observed. Multiple non-specific bands may appear on western blot. View All» Epitope: N-terminus of mature chain View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of the mature chain of mouse NODAL. View All» Background Information: NODAL is a highly conserved, secreted homodimer belonging to the TGF-beta family of proteins involved in developmental regulation. One of the most prominent, endogenous molecules observed at this early stage, NODAL stimulates the formation of both the endoderm and mesoderm, designates the embryonic axis, and is necessary to the asymmetrical development of organs such as the brain, heart, and visceral organs. It is also a crucial component for embryonic stem (ES) cell differentiation into specific tissue lineages. In cooperation with activin, NODAL signaling has been shown to play a role in maintaining ES cell pluripotency by regulating Nanog expression. View All» Species Reactivity:

• Mouse

• Human

• Pig

• Horse

• Chimpanzee

• Rhesus Macaque

• Rat

• Rabbit
  View All» Species Reactivity Note: Demonstrated to react with mouse and human. Predicted to react with porcine, equine, chimpanzee, rhesus macaque, rat, and rabbit based on 100% sequence homology. View All» Application Notes: Western Blot (Snap i.d.®) Analysis: 5 µg/mL of this antibody detected NODAL in 10 µg of mouse E7 fetus tissue lysate.Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected NODAL in metastatic endometrial carcinoma and colorectal carcinoma tissue.Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected NODAL in mouse embryonic stem cells. View All» Control: Mouse E7 fetus tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse E7 fetus tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected NODAL in 10 µg of mouse E7 fetus tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P43021 View All» Entrez Gene Number: NP_038639 View All» Gene Symbol:
  • NODAL

  • Nodal
    View All» Alternate Names:
    • nodal homolog (mouse)

    • nodal, mouse, homolog
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Essential for mesoderm formation and axial patterning during embryonic development. SUBUNIT STRUCTURE: Homodimer; disulfide-linked (By similarity).SUBCELLULAR LOCATION: Secreted (By similarity). DEVELOPMENTAL STAGE: Expressed in the node during gastrulation. Expression is first detected in primitive streak-stage embryos at about the time of mesoderm formation. It then becomes highly localized in the node at the anterior of the primitive streak. SEQUENCE SIMILARITIES: Belongs to the TGF-beta family. View All» Product Name: Anti-NODAL View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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