货号：AB3879

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Acetyl Lysine Antibody | AB3879 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes proteins acetylated on lysine residues. This antibody recognizes multiple acetylated proteins including acetylated histones, acetylated BSA, and acetylated MBP, and exhibits no reaction with non-acetylated proteins. View All» Immunogen: Acetylated KLH. View All» Modifications: Acetylation View All» Background Information: In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation. View All» Species Reactivity: All View All» Species Reactivity Note: Reacts with all species. View All» Application Notes: Immunoprecipitation: A previous lot was used at 10 µg/mg crude protein.ELISA: 0.25-1 μg/mL of a previous lot was used.Immunohistochemistry: 2.5 μg/mL of a previous lot was used.Immunofluorescence: 5 μg/mL of a previous lot was used.Optimal working dilutions must be determined by end user. View All» Control: TSA-treated HeLa and NIH/3T3 cells, osteosarcoma tissue. View All» Quality Assurance: Routinely evaluated by Western Blot on Hela Acid Extract/Sodium Butyrate lysates.Western Blot Analysis: 1:500 dilution of this lot detected lysine acylated proteins on 10 μg of Hela Acid Extract/Sodium Butyrate lysates. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 50% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C in undiluted aliquots from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• ELISA

• Immunofluorescence

• Immunohistochemistry

• Immunoprecipitation

• Western Blotting
  View All» Brand Family: Chemicon View All» Product Name: Anti-Acetyl Lysine Antibody | AB3879 View All» Concentration: Please refer to lot specific datasheet. View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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