货号：AB3582P

品牌：Merck Millipore

规格：50MIG

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cyclic Nucleotide-Gated Channel 1 Antibody, C-terminus | AB3582P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Cyclic Nucleotide-Gated Channel 1 (CNG1). The immunogen shows no significant sequence homology with other CNG's. SPECIES REACTIVITIES: The immunogen sequence is 100% conserved in porcine, 80% in bovine, 70% in canine and 57% in rat. Reactivity with other species has not been confirmed. View All» Epitope: C-terminus View All» Immunogen: A 20 amino acid peptide sequence near the N-terminus of human CNG1 (Dhallan et al. 1992; Distler et al. 1994; Bonigk et al. 1993). View All» Species Reactivity:

• Human

• Pig
  View All» Application Notes: Western blot: 1-10 g/mL using ECL.ELISA: 0.5-1 g/mL using 1 g/mL control peptide per well.Immunohistochemistry: not tested. It is recommended that the antibody be tried at 2-20 μg/mL on paraformaldehyde fixed tissue.Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. View All» UniProt Number: P29973 View All» Entrez Gene Number: NM_000087.2 View All» Gene Symbol:
  • CNGA1

  • CNCG

  • RCNCalpha

  • CNG-1

  • RCNC1

  • CNCG1

  • RCNCa

  • CNG1
    View All» Alternate Names: CNG1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P29973 # Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.SIZE: 686 amino acids; 79126 Da SUBUNIT: Homotetramer or higher oligomer. Forms heterooligomeric complex with CNG4.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Rod cells in the retina.DISEASE: SwissProt: P29973 # Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.SIMILARITY: SwissProt: P29973 ## Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. & Contains 1 cyclic nucleotide-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Cyclic Nucleotide-Gated Channel 1 Antibody, C-terminus | AB3582P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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