货号：AB16943

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DcR2 Antibody, intracellular domain | AB16943 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (Pan et al. 1997a,b; Sheridan et al. 1997). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (Marsters et al. 1997; Degli-Esposti et al. 1997; Pan et al. 1997). DcR2 has an extracellular TRAIL binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis. View All» Epitope: intracellular domain View All» Immunogen: Polyclonal antibody raised against a peptide corresponding to amino acids 249-263 of human DcR2 precursor (Marsters et al. 1997; Degli-Esposti et al. 1997; Pan et al. 1997). View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:100 to 1:4000Immunohistochemistry: 10 µg/mLWhole cell lysate from HeLa cells can be used as a positive control . Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q9UBN6 View All» Entrez Gene Number: NM_003840.3 View All» Gene Symbol:

• TNFRSF10D

• CD264

• DcR2

• TRUNDD

• TRAIL-R4

• TRAILR4

• DCR2
  View All» Alternate Names: TRAIL-R4; TRUNDD View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. View All» UniProt Summary: FUNCTION: SwissProt: Q9UBN6 # Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway (According to PubMed:9382840 it cannot but according to PubMed:9430226 it can induce the NF-kappa-B pathway).SIZE: 386 amino acids; 41823 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.SIMILARITY: SwissProt: Q9UBN6 ## Contains 1 death domain. & Contains 3 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-DcR2 Antibody, intracellular domain | AB16943 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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