货号：AB10140

品牌：Merck Millipore

规格：100Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Drebrin A/E Antibody | AB10140 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB10140 detects the internal domain of Drebrin A/E. View All» Molecular Weight: ~77 kDa View All» Epitope: Internal Domain View All» Immunogen: KLH conjugated synthetic linear peptide. View All» Background Information: The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast View All» Species Reactivity:

• Mouse

• Rat

• Human
  View All» Species Reactivity Note: Mouse and Rat. May react with human based on sequence homology. Reactivity with other species has not been determined. View All» Application Notes: Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University. View All» Control: Embryonic rat brain (day 16) tissue lysate. View All» Quality Assurance: Western Blot:A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate. View All» Purification Method: Antigen affinity purified View All» Presentation: Purified rabbit polyclonal antibody in PBS with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q07266 View All» Entrez Gene Number: NM_004395.3 View All» Gene Symbol:
  • D0S117E

  • DKFZp434D064

  • drebrin-1
    View All» Alternate Names:
    • Developmentally-regulated brain protein

    • drebrin 1

    • drebrin E

    • drebrin E2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively.SUBUNIT STRUCTURE: Binds F-actin.SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Brain neurons.MISCELLANEOUS: Drebrins are classified into two forms of the embryonic type (E1 and E2) and one form of the adult type (A). The time course of their appearance are different from each other. Their structures are closely related. Adult rat brain expresses only drebrin A while drebrin E1 or E2 is observed in immature animals.SEQUENCE SIMILARITIES: Contains 1 ADF-H domain. View All» Product Name: Anti-Drebrin A/E View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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