货号：14-865

品牌：Merck Millipore

规格：1EA

目录价：￥6858.58

市场价格：￥5829.79

会员价格：￥5486.86

金山科研平台，产品价格货期咨询微信：jinshanbio Description: p53-GST (recombinant protein) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: N-terminal GST-tagged, recombinant full length human P53 protein, expressed in E. coli. Purified using glutathione agarose chromatography. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq] View All» Species: Human View All» Molecular Weight: 72 kDa View All» Brand Family: Upstate View All» Source: Full-length human p53 protein, expressed in e. coli. View All» Presentation: Recombinant protein in buffer containing 20 mM Tris-HCl, pH 8.0, 100 mM KCl, 5mM glutathione, 0.5 mM EDTA, 0.5 mM DTT, 1 mM PMSF containing 20% glycerol. View All» Storage Conditions: 1 year at -20°C View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Gene Symbol:

• p53

• TP53

• tumor protein p53

• TRP53

• FLJ92943

• LFS1
  View All» Product Name: p53-GST (recombinant protein) View All» Alternate Names: transformation related protein 53 View All» Concentration: 0.5 mg/mL View All» Quality Assurance: Routinely evaluated by SDS-PAGE and Coomassie Stain View All» UniProt Number: P04637 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NP_000537 View All» Purity: ~95% by SDS-PAGE View All» Purification Method: Glutathione agarose chromatography View All»
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