货号：14-861

品牌：Merck Millipore

规格：

目录价：￥4317.00

市场价格：￥3669.45

会员价格：￥3453.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: CHIP, recombinant View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: Recombinant fusion protein containing human CHIP with an N-terminal His-tag, expressed in E. coli. View All» Key Applications: Activity Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: Q9UNE7 # Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.SIZE: 303 amino acids; 34856 Da SUBUNIT: Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.PTM: Auto-ubiquitinated (in vitro). & Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE:SwissProt: Q9UNE7 # Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients.SIMILARITY: SwissProt: Q9UNE7 ## Contains 3 TPR repeats. & Contains 1 U-box domain. View All» Species: Human View All» Molecular Weight: 38 kDa View All» Brand Family: Upstate View All» Source: Expressed in E. coli View All» Presentation: 50 µg recombinant CHIP in 50 µL of 50mM Tris-HCl, pH 7.5, 270mM Sucrose, 150mM NaCl, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.02% Brij-35, 0.2mM PMSF, and 1mM Benzamidine. Frozen solution. View All» Storage Conditions: Stable for 2 years at -70°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» Gene Symbol:

• STUB1

• SDCCAG7

• HSPABP2

• CHIP

• NY-CO-7

• UBOX1
  View All» Product Name: CHIP, recombinant View All» Alternate Names: Carboxyl terminus of Hsp70-Interacting Protein, STIP1 homology and U-box containing protein 1 View All» Quality Assurance: Routinely evaluated by ubiquitin assay View All» UniProt Number: Q9UNE7 View All» Entrez Gene Number: NM_005861.2 View All» Purity: ~90% by SDS PAGE and Coomassie blue staining. View All» Purification Method: ProBond Resin chromatography View All»
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