货号：14-249

品牌：Merck Millipore

规格：10Ug

目录价：￥6586.00

市场价格：￥5598.10

会员价格：￥5268.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: p38δ/SAPK4, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: Recombinant GST fusion protein fused to full length human p38δ/SAPK4CHK3 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. View All» UniProt Summary: FUNCTION: SwissProt: O15264 # Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K.COFACTOR: Magnesium.SIZE: 365 amino acids; 42090 Da TISSUE SPECIFICITY: Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.DOMAIN: SwissProt: O15264 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 71kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Protein Target: p38δ/SAPK4 View All» Storage Conditions: 6 months at -20°C View All» Target Sub-Family: CMGC View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• MAPK13

• MGC99536

• PRKM13

• SAPK4

• p38delta
  View All» Product Name: p38δ/SAPK4, active View All» Quality Assurance: Routinely evaluated by phosphorylation of MBP in vitro View All» UniProt Number: O15264 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_002754.3 View All» Purification Method: Affinity chromatography on glutathione Sepharose™ beads after activation with SKK3/MEK6 View All»
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