Merck Millipore代理07-463 Anti-trimethyl-Histone H4 (Lys20) Antibody;store at +2℃ to +8℃

2025-07-23

货号:07-463

品牌:Merck Millipore

规格:100Ug

目录价:¥6127.00

市场价格:¥5207.95

会员价格:¥4901.60

金山科研平台,产品价格货期咨询微信:jinshanbio Description: Anti-trimethyl-Histone H4 (Lys20) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of Histone H4 trimethylated at Lys20. View All» Molecular Weight: ~13 kDa observed. An uncharacterized band may appear at ~110 kDa in some lysates. View All» Epitope: Trimethylated Lys20 View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human Histone H4 trimethylated at Lys20. View All» Background Information: Histones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli, including phosphorylation on serine and threonine residues and methylation on lysine residues. PTMs produce configural changes in histone proteins that may induce nucleosome remodeling and expose or hide DNA sequences from transcriptional complexes. Histone H4 lysine 20 (H4K20) may undergo mono-, di-, or trimethylation, which is catalyzed by the methyltransferase PR-Set7 (Set8 or KMT5a). Methylated H4K20 plays a role in regulating DNA damage responses, mitosis, DNA replication, and gene expression. Trimethylation of H4K20 contributes to gene silencing, and is a mark of the repressive heterochromatin state. View All» Species Reactivity:

  • Human

  • Mouse

  • Rat

    View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Western Blot Analysis: 2 µg/mL from a representative lot detected trimethyl-Histone H4 (Lys20) in 10 µg of BALB3T3/A31 acid extract and RAT2 acid extract.Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see tables) were probed with Anti-trimethyl-Histone H4 (Lys20) (4 µg/mL).Chromatin Immunoprecipitation Analysis: A representative lot immunoprecipitated Histone H4 using chromatin from HeLa cells.Immunoprecipitation Analysis: A representative lot immunoprecipitated trimethyl-Histone H4 (Lys20) from HeLa cell lysate. View All» Control: HeLa acid extract and various recombinant Histone proteins. View All» Quality Assurance: Evaluated by Western Blot in HeLa acid extract and various recombinant Histone proteins.Western Blot Analysis: 2 µg/mL of this antibody detected trimethyl-Histone H4 (Lys20) in 10 µg of HeLa acid extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P62805 View All» Entrez Gene Number: NP_001029249 View All» Gene Symbol:
    • HIST1H4A

    • H4/J

    • HIST1H4F

    • HIST1H4L

    • H4FN

    • H4FA

    • H4FH

    • HIST1H4H

    • H4F2

    • H4FM

    • H4/A

    • H4FK

    • H4FG

    • HIST2H4

    • H4FB

    • H4/K

    • HIST1H4I

    • H4/N

    • HIST1H4B

    • H4FE

    • H4/M

    • H4/a

    • HIST1H4E

    • HIST4H4

    • HIST2H4A

    • H4FC

    • H4FI

    • H4/H

    • HIST1H4C

    • H4/G

    • HIST1H4K

    • H4FJ

    • H4FD

    • H4/I

    • H4/B

    • H4/C

    • H4/D

    • HIST1H4J

    • HIST1H4D

    • H4/E

      View All» Alternate Names:
      • H4K20me3

      • Histone H4 (tri methyl K20)

      • H4 histone family, member A

      • histone 1, H4a

      • histone cluster 1, H4a

        View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
        • Immunoprecipitation

        • Western Blotting

        • Dot Blot

          View All» Product Name: Anti-trimethyl-Histone H4 (Lys20) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»

          © 金山科研平台是专业的授权总代理区域代理经销平台。
          © 如需询价,请加客服QQ:1749072012 、客服微信:jinshanbio,或发送邮件到1749072012@qq.com
          © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务,数据资源基于CC协议。
          © 本文地址:http://16ao.com/thread-135786.htm
          © Merck Millipore代理07-463 Anti-trimethyl-Histone H4 (Lys20) Antibody;store at +2℃ to +8℃,产品报价联系微信jinshanbio
产品询价需求提交
产品询价请加微信:jinshanbio
返回