货号：07-1548

品牌：Merck Millipore

规格：400Ul

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HDAC11 Antibody | 07-1548 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes HDAC11. View All» Molecular Weight: ~40 kDa View All» Epitope: N-terminus View All» Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding the N-terminal region of human HDAC11. View All» Background Information: HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human, Mouse. Not tested in other species. View All» Application Notes: ELISA:This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000).Immunohistochemistry:This antibody has been shown by an outside laboratory to be suitable for histochemistry using formalin fixed, paraffin embedded human hepatocarcinoma tissue (1:50-1:100). View All» Control: Mouse Brain cell lysate View All» Quality Assurance: Western Blot Analysis:Detection of HDAC11 in 10 µg of Mouse Brain lysate by Western blot analysis. View All» Purification Method: Protein G chromatography View All» Presentation: Purified rabbit polyclonal in buffer containing 0.09% NaN3. View All» Storage Conditions: Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q96DB2 View All» Entrez Gene Number: NP_079103 View All» Gene Symbol:
  • HD11

  • FLJ22237

  • EC 3.5.1.98
    View All» Alternate Names: histone deacetylase 11 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • ELISA

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). View All» UniProt Summary: FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Ref.4Catalytic activity Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.SUBUNIT STRUCTURE: Interacts with HDAC6. Ref.4SUBCELLULAR LOCATION: Nucleus. Note= Predominantly nuclear.TISSUE SPECIFICITY: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.MISCELLANEOUS: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.SEQUENCE SIMILARITY: Belongs to the histone deacetylase family.SEQUENCE CAUTION:The sequence BAB15127.1 differs from that shown. Reason: Erroneous termination at position 107. Translated as Gln.The sequence CAB70712.1 differs from that shown. Reason: Frameshift at positions 177, 198 and 200. View All» Product Name: Anti-HDAC11 Antibody (07-1548) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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