Merck Millipore代理07-1494 Anti-Calcineurin Ba (rabbit polyclonal)

2025-07-24

货号:07-1494

品牌:Merck Millipore

规格:

目录价:¥3908.00

市场价格:¥3321.80

会员价格:¥3126.40

金山科研平台,产品价格货期咨询微信:jinshanbio Description: Anti-Calcineurin Bα Antibody | 07-1494 View All» Replaces: 07-1494 is a recommended replacement for AB1699. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Specific for the Balpha isoform of the CnB regulatory subunit of calcineurin. CnBalpha is the predominant gene for the regulatory subunit of calcineurin in most tissues. CnBbeta is, a testis-enriched isoform. The antibody reacts with CnBalpha subunits of calcineurin of all mammalian species so far tested. View All» Molecular Weight: 18-20 kDa band in western blot. View All» Immunogen: Synthetic peptide (KASYPLEMCSHFD) coupled to KLH. View All» Isotype: IgG View All» Background Information: Calcineurin/PP2B is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin/PP2B has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin/PP2B's multifunctional capabilities in the regulation of calcium signaling. View All» Species Reactivity:

  • Human

  • Mouse

  • Rat

  • Mammals

    View All» Species Reactivity Note: Human, Mouse and Rat.Broad reactivity is expected for mammals. View All» Application Notes: Immunohistochemisty (paraffin): Calcineurin Bα representative staining pattern/morphology in normal human placenta. Tissue was pretreated with citrate pH 6, antigen retrieval. A previous lot of this antibody was diluted to 1:100, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen here in nutrient rich erythrocytes for both mother and embryo blood.Optimal working dilutions must be determined by end user. View All» Control: A431 cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on A431 lysates. Western Blot Analysis: 1:500-1:1,000 dilution of this lot detected Calcineurin Bα on 10 μg of A431 lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing TBS, 40% glycerol as a cryopreservative and no preservatives. View All» Storage Conditions: Stable for 1 year at -20°C in undiluted aliquots from date of receipt; at this temperature the solution will remain unfrozen. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage. View All» UniProt Number: P63098 View All» Entrez Gene Number: NM_000945.3 View All» Gene Symbol:
    • PPP3R1

    • CALNB1

    • CNB

    • CNA2

    • CNB1

      View All» Alternate Names: CnBalpha View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)

        View All» UniProt Summary: FUNCTION: SwissProt: P63098 # Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.SIZE: 170 amino acids; 19300 Da SUBUNIT: Composed of a catalytic subunit (A) and a regulatory subunit (B).SIMILARITY: SwissProt: P63098 ## Contains 4 EF-hand domains. MISCELLANEOUS: This protein has four functional calcium-binding sites. View All» Product Name: Anti-Calcineurin Bα Antibody | 07-1494 View All» Concentration: 0.7 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»

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