货号：06-1119

品牌：Merck Millipore

规格：100Ug

目录价：￥4015.00

市场价格：￥3412.75

会员价格：￥3212.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TLR2 Antibody | 06-1119 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the extracellular domain of TLR2. View All» Molecular Weight: ~90 kDa observed. Blocking without Tween is recommended to avoid the observance of additional bands. View All» Epitope: Extracellular Domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the extracellular domain of human TLR2. View All» Background Information: Toll-like receptor 2 (TLR2) is a single-pass type I membrane protein belonging to the Toll-like receptor family and is comprised of 14 LRR repeats and a single TIR domain. TLR2 interacts with LY96 or TLR1 to regulate innate immune response to bacterial lipoproteins and other components of the microbial cell wall. It induces the activation of NFκB, inflammatory response and cytokine secretion through interactions with MYD88 and TRAF6. It may also function as a promoter for apoptosis. High expression of TLR2 has been reported in blood leukocytes, specifically in bone marrow, lymph node, monocytes and spleen. It has also been observed in fetal liver and lung tissues. Modifications in gene expression have been implicated in an increased susceptibility to leprosy. View All» Species Reactivity:

• Mouse

• Human

• Chimpanzee

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with chimpanzee and rhesus macaque based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:50 dilution from a previous lot detected TLR2 in normal human placenta tissue. View All» Control: RAW264.7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in RAW264.7 cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected TLR2 in 10 µg of RAW264.7 cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O60603 View All» Entrez Gene Number: NP_003255 View All» Gene Symbol:
  • TLR2

  • TIL4

  • CD282
    View All» Alternate Names:
    • toll-like receptor 2

    • Toll/interleukin-1 receptor-like protein 4

    • toll/interleukin 1 receptor-like 4

    • CD282 antigen
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.SIZE: 784 amino acids; 89838 Da SUBUNIT: Binds LY96 and TLR6 via the extracellular domain. Binds MYD88 via their respective TIR domains.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.PTM: Glycosylation of Asn-442 is critical for secretion of the N- terminal ectodomain of TLR2.SIMILARITY: Belongs to the Toll-like receptor family. & Contains 14 LRR (leucine-rich) repeats. & Contains 1 TIR domain. ... View All» Product Name: Anti-TLR2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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