货号：05-900

品牌：Merck Millipore

规格：EA

目录价：￥3372.00

市场价格：￥2866.20

会员价格：￥2697.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Met (Tyr1234/1235) Antibody, clone NL8 | 05-900 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: phosphorylated Met, cross-reacts with phosphorylated EGFR View All» Molecular Weight: Mr 140kDa View All» Immunogen: KLH-conjugated, synthetic peptide (...KE[pY][pY}SV...) in which pYpY corresponds to phosphorylated amino acids 1234 and 1235 of human Met/HGFR View All» Modifications: Phosphorylation View All» Clone: NL8 View All» Isotype: IgG View All» Species Reactivity: Human View All» Species Reactivity Note: Broad species cross-reactivity expected due to sequence homology View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from NIH-3T3 cells co-expressing Met/HGFR and HGF View All» Purification Method: Protein A purfied View All» Storage Conditions: stable 2 years at -20°C from date of shipment View All» UniProt Number: P08581 View All» Entrez Gene Number: NM_000245 View All» Gene Symbol:

• MET

• HGFR

• AUTS9

• c-Met

• RCCP2
  View All» Alternate Names: c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. View All» UniProt Summary: FUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.SIZE: 1390 amino acids; 155527 Da SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DISEASE: SwissProt: P08581 # Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. & Defects in MET may be associated with gastric cancer. & Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. & Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. & Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.SIMILARITY: SwissProt: P08581 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 3 IPT/TIG domains. & Contains 1 protein kinase domain. & Contains 1 Sema domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-Met (Tyr1234/1235) Antibody, clone NL8 | 05-900 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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