货号：MABF117

品牌：Merck Millipore

规格：100MIG

目录价：￥3314.00

市场价格：￥2816.90

会员价格：￥2651.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1 | MABF117 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 18 kDa calculated View All» Immunogen: Mouse MD-2 and HEK293 cells stably expressing TLR4 and MD-2. View All» Clone: IIC1 View All» Isotype: IgMκ View All» Background Information: Myeloid Differentiation-2 (MD-2) is a small secreted glycoprotein that binds with cytokine-like affinities to both the hydrophobic portion of lipopolysaccharides (LPS) and the extracellular domain of Toll-like Receptor 4 (TLR4). TLR-4 is activated by its natural ligand(s), the presence of extracellular MD-2, and most lipopolysaccharides (glycan complexes which may be produced by Gram-negative bacteria). MD-2 also interacts with TLR2 in response to cell wall components of Gram-positive and Gram-negative bacteria. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Flow Cytometry Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in human monocytes and HEK293 cells stably expressing Flag-tagged MD2. (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)Immunocytometry Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in human monocites. (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)Western Blot Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in CHO cell lysates expressing MD2 and Flag-tagged MD2 (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)ELISA Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in supernatent from unstimulated and IL-10 stimulated human monocytes. (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.) View All» Control: PBMC cells. View All» Quality Assurance: Evaluated by Flow Cytometry in PBMC cells.Flow Cytometry Analysis: 1 µg/mL of this antibody detected Myeloid differentiation-2 in 1X10E5 PBMC cells. View All» Purification Method: Purified by ion-exchange chromatography View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y6Y9 View All» Entrez Gene Number: NP_001182726 View All» Gene Symbol:

• LY96

• ESOP1

• MD2
  View All» Alternate Names:
  • Lymphocyte antigen 96

  • Ly-96

  • ESOP-1

  • Protein MD-2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunocytochemistry

    • Western Blotting

    • ELISA
      View All» Entrez Gene Summary: This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. View All» UniProt Summary: FUNCTION: Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.SUBUNIT STRUCTURE: Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binds to the extracellular domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex.SUBCELLULAR LOCATION: Secreted › extracellular space. View All» Product Name: Anti-Myeloid differentiation-2 (MD-2), clone IIC1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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