货号：MABD78

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AFP Antibody, clone 1E4 | MABD78 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~66 kDa observed View All» Immunogen: Recombinant protein corresponding to human AFP. View All» Clone: 1E4 View All» Isotype: IgG2aκ View All» Background Information: AFP (alpha-fetoprotein) is a fetal serum protein that shows an increased expression in many different clinical conditions and has been associated with hepatocellular carcinoma and germ cell tumors. It has also been linked to the development of gastric cancer. Women with pregestational diabetes have commonly shown a decrease in maternal serum AFP during the second trimester. AFP has been used as a pregnancy monitoring biomarker in many different mammalian species. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HepG2 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected AFP on 10 µg of HepG2 cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P02771 View All» Entrez Gene Number: NP_001125 View All» Gene Symbol:

• AFP

• HPAFP
  View All» Alternate Names:
  • Alpha-fetoprotein

  • Alpha-1-fetoprotein

  • Alpha-fetoglobulin
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.SUBUNIT STRUCTURE: Dimeric and trimeric forms have been found in addition to the monomeric form.SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICTY: Plasma. Synthesized by the fetal liver and yolk sac.DEVELOPMENTAL STAGE: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.PTM: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.Sulfated.SEQUENCE SIMILARITIES: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains. View All» Product Name: Anti-AFP, clone 1E4 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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