货号：MABC13

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TRAIL-R2 (CD262) Antibody, clone MD5-1 | MABC13 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 42 kDa calculated View All» Immunogen: Recombinant protein corresponding to mouse TRAIL-R2. View All» Clone: MD5-1 View All» Isotype: IgG View All» Background Information: TRAIL-R2 (CD262) is one of two pro-apoptotic receptors activated by the TNF-related apoptosis-inducing ligand (sTRAIL or Apo-2L). Ligand-bound TRAIL receptors form trimeric structures at the plasma membrane around a central zinc atom. The trimeric TRAIL receptors bind the FADD adaptor protein which in turn recruits caspase 8. TRAIL/APO-2L signals ultimately converge on caspase 3 and related proteins that promote cell death. Importantly, activated TRAIL receptors work cooperatively with death receptors 4 and 5 in transformed cells to induce caspase signaling, thereby preventing the proliferation of abnormal cells. TRAIL/ApO-2L has been implicated in pathophysiology of many disease processes, including cancer and autoimmune diseases. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. View All» Control: NIH/3T3 cells View All» Quality Assurance: Evaluated by Flow Cytometry in NIH/3T3 cells.Flow Cytometry Analysis: A 1:250 dilution of this antibody detected TRAIL-R2 in NIH/3T3 cells. View All» Purification Method: Protein G purified View All» Presentation: Purified hamster monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9QZM4 View All» Entrez Gene Number: NP_064671 View All» Gene Symbol:

• Tnfrsf10b

• Dr5

• Killer
  View All» Alternate Names:
  • Tumor necrosis factor receptor superfamily member 10B

  • TRAIL-R2

  • Death receptor 5

  • MK

  • CD262
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Product Name: Anti-TRAIL-R2 (CD262), clone MD5-1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Hamster View All»
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