货号：05-1311

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl Histone H3 (Lys14) Antibody, clone 10H8.2 | 05-1311 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes histone H3 acetylated on Lys14, Mr 17 kDa. View All» Molecular Weight: ~17 kDa View All» Epitope: Acetyl Lys14 View All» Immunogen: KLH-conjugated, synthetic peptide containing the sequence (ARKSTGGA(Acetyl-K) APRGC, corresponding to the sequence surrounding acetylated lysine 14 of human histone H3. View All» Modifications: Acetylation View All» Clone: 10H8.2 View All» Isotype: IgG1κ View All» Background Information: Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). Histone H3 is acetylated on Lys14 by Gcn5, and histone H3 phosphorylation at Ser10 facilitates acetylation of Lys14 by Gcn5 in vitro. Moreover, Lys14 is involved in chromatin remodeling, and RSC4 (part of the RSC chromatin remodeling complex) contains essential tandem bromodomains that require H3 Lys14 acetylation for gene activation. View All» Species Reactivity: Human View All» Species Reactivity Note: Based on sequence homology, broad species cross-reactivity is expected. View All» Control: Sodium butyrate-treated HeLa cell acid extracts. View All» Quality Assurance: Routinely evaluated by Western BlotWestern Blot Analysis: A 1 μg/mL dilution of a recent lot detected acetylated histone H3 (Lys14) in acid extracts of sodium butyrate-treated HeLa cells. View All» Purification Method: Protein G purfied View All» Presentation: Purified from ascites by protein G chromatography. Supplied at 1 mg/ml in PBS, 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.For maximum recovery of product, centrifuge the vial prior to removing the cap. View All» UniProt Number: P68431 View All» Entrez Gene Number: NP_003520.1 View All» Alternate Names:

• H3K14Ac

• Histone H3 (acetyl K14)

• HIST1H3
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. View All» UniProt Summary: FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Subunit structure: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.Subcellular location: Nucleus. Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.Post-translational modification: Acetylation is generally linked to gene activation. Acetylation on Lys-10 impairs methylation at Arg-9. Acetylation on Lys-19 and Lys-24 favors methylation at Arg-18. View All» Brand Family: Upstate View All» Product Name: Anti-acetyl Histone H3 (Lys14), clone 10H8.2 View All» Concentration: 1 mg/ml View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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