货号：04-795

品牌：Merck Millipore

规格：100UL

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Ribosomal Protein S6 (Ser235) Antibody, clone MC27 | 04-795 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes ribosomal protein S6 only when phosphorylated on Ser235. View All» Molecular Weight: ~30 kDa View All» Epitope: Phosphorylated Ser235 View All» Immunogen: Synthetic peptide containing the sequence …RRL[pS]SL… in which pS corresponds to phospho-serine at residue 235 of human ribosomal protein S6. The immunizing sequence is identical in mouse, rat, chicken and Xenopus. View All» Modifications: Phosphorylation View All» Clone: MC27 View All» Isotype: IgG View All» Background Information: S6 (Ribosomal protein S6, RpS6, 40S ribosomal protein S6) is known to play a role in cell growth and proliferation. It lays downstream of both the PI3K/Akt/mTOR pathway as a substrate of p70 S6 kinase and the Ras/Erk pathway as a substrate of RSK. S6 is phosphorylated in response to stimulation by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. There are two major areas of S6 phosphorylation; Ser235/Ser236 that is known to be phosphorylated by both p70S6 Kinase as well as RSK as well as Ser240/244 which is thought to only be phosphorylated by p70S6K. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, rat and mouse. Broad species cross-reactivity predicted, due to sequence homology. View All» Application Notes: Western Blot Analysis: A 1:500-1:2,000 dilution of this lot detected phosphorylated ribosomal protein S6 in lysates from serum stimulated 3T3 cells. View All» Control: Serum stimulated 3T3 cell lysate. View All» Quality Assurance: Routinely evaluated by western blot on serum stimulated 3T3 cell lysate. View All» Presentation: Cultured supernatant with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P62753 View All» Entrez Gene Number: NM_001010.2 View All» Gene Symbol:
  • 40S ribosomal protein S6

  • Phosphoprotein NP33

  • ribosomal protein S6

  • RPS6
    View All» Alternate Names:
    • 40S ribosomal protein S6

    • Phosphoprotein NP33

    • ribosomal protein S6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq] View All» UniProt Summary: FUNCTION:May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.PTM: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13SIMILARITIES: Belongs to the ribosomal protein S6e family. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-Ribosomal Protein S6 (Ser235), clone MC27 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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