货号：04-1550

品牌：Merck Millipore

规格：100UL

目录价：￥5215.00

市场价格：￥4432.75

会员价格：￥4172.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SC-35 Antibody, clone 1SC-4F11 | 04-1550 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes SC35. View All» Molecular Weight: ~ 35 kDa View All» Epitope: Unknown View All» Immunogen: Ovalbumin-conjugated linear peptide corresponding to human SC35. View All» Isotype: IgG1κ View All» Background Information: SC-35 is also known as Splicing factor SC35 and Splicing factor, arginine/serine-rich 2. This protein is encoded by the SFRS2 gene and is a member of the splicing factor SR family. SC-35 is involved in pre-mRNA splicing and is found in bodies in the nucleus that are highly enriched in poly(A) RNA. These nuclear bodies are referred to as speckles, SC 35 domains, or splicing factor compartments (SFCs). The purpose of these bodies is still widely disputed. Speckles correspond largely to, if not entirely to, ultra structures called inter-chromatin granule clusters (IGCs). SC3-35 is required for pre-mRNA splicing events and is highly involved in spliceosomal interaction and assembly. SC-35 is necessary for assembly of the ATP-dependent splicing complex. It is also necessary for the ATP-dependent communication between pre-mRNA and U1 and U2 snRNPs. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, rat. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected SC35 in NIH/3T3 cells. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected Sc35 on 10 µg of A431 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified mouse monoclonal IgG1κ preservative-free ascites. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q01130 View All» Entrez Gene Number: NP_003007.2 View All» Gene Symbol:
  • SFRS2

  • PR264

  • SC-35

  • SC35

  • SFRS2A

  • SRp30b
    View All» Alternate Names:
    • Protein PR264

    • Splicing component, 35 kDa

    • Splicing factor SC35

    • splicing factor, arginine/serine-rich 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway.SUBUNIT STRUCTURE: In vitro, binds SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SFRS2IP. SUBCELLULAR LOCATION: Nucleus. PTM: Extensively phosphorylated on serine residues in the RS domain. SEQUENCE SIMLARITIES: Belongs to the splicing factor SR family.Contains 1 RRM (RNA recognition motif) domain. View All» Product Name: Anti-SC-35, clone 1SC-4F11 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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