货号：MAB3536

品牌：Merck Millipore

规格：100Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Lamin B2 Antibody, clone LN43 | MAB3536 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Lamin B2. Recognizes an epitope located in the C-terminal part of lamin B2. View All» Immunogen: Detergent insoluble fraction of potoroo cell line PtK1 View All» Clone: LN43 View All» Isotype: IgG1 View All» Background Information: Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. View All» Species Reactivity:

• Human

• Hamster

• Mouse

• Xenopus
  View All» Application Notes: Western blotting: 1:100-1:1,000; nuclear preparations recommended; detects 67-68kDa lamin B2 protein Immunocytochemistry on fixed cells (methanol/acetone fixation): 1:100-1:200.Flow cytometry: 1:100-1:200. Optimal working dilutions must be determined by the end user. View All» Presentation: Purified culture supernatant. Liquid in PBS containing 0.09% sodium azide. View All» Storage Conditions: Maintain -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q03252 View All» Entrez Gene Number: NM_032737.2 View All» Gene Symbol:
  • LMNB2

  • Lamin-B2.

  • LMN2

  • MGC2721

  • LAMB2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B2. This gene is in a head-to-tail orientation with the gene for the translocase of inner mitochondrial membrane 13 homolog gene. View All» UniProt Summary: FUNCTION: SwissProt: Q03252 # Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.SIZE: 600 amino acids; 67689 Da SUBCELLULAR LOCATION: Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.PTM: B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.DISEASE: SwissProt: Q03252 # Defects in LMNB2 are a cause of partial acquired lipodystrophy (APL) [MIM:608709]; also called Barraquer-Simons syndrome. APL is a rare childhood disease characterized by loss of subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidaemia, and complement deficiency. Mental retardation in some cases. APL is a sporadic disorder of unknown aetiology.SIMILARITY: SwissProt: Q03252 ## Belongs to the intermediate filament family. MISCELLANEOUS: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. View All» Brand Family: Chemicon View All» Product Name: Anti-Lamin B2 Antibody, clone LN43 | MAB3536 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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