货号：MAB3520

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ubiquitin Activating Enzyme E1 Antibody, clone 2G2.3 | MAB3520 View All» Replaces: 05-624 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody specifically binds to ubiquitin activation enzyme E1. The antibody does not inhibit the enzymatic activity of E1. View All» Immunogen: Ubiquitin activating enzyme E1. View All» Clone: 2G2.3 View All» Isotype: IgG1 View All» Background Information: The proteosome has long been thought of as the default mechanism for waste elimination within the cell. Recently, however, the proteosome has been recognized as an essential organelle necessary for the processing of antigens, the transcription factor NFkB and other proteins as well. Central to the function of the proteosome is the ubiquitinization of target proteins by a number of unique ubiquitin activation enzymes. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blot: 2-4 μg/mL Immunohistochemistry Immunoprecipitation Sero-depletion Optimal working dilutions must be determined by end user. View All» Presentation: Liquid. Buffer = 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6, with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: P22314 View All» Entrez Gene Number:
  • NM_003334.2

  • NM_153280.1
    View All» Gene Symbol:
    • UBA1

    • UBE1X

    • MGC4781

    • A1S9T

    • UBA1A

    • A1S9

    • UBE1

    • A1ST

    • GXP1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. View All» UniProt Summary: FUNCTION: SwissProt: P22314 # Activates ubiquitin by first adenylating with ATP its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.SIZE: 1058 amino acids; 117849 Da SUBUNIT: Monomer (By similarity).SIMILARITY: SwissProt: P22314 ## Belongs to the ubiquitin-activating E1 family. MISCELLANEOUS: There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. View All» Brand Family: Chemicon View All» Product Name: Anti-Ubiquitin Activating Enzyme E1 Antibody, clone 2G2.3 | MAB3520 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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