货号：MAB2620

品牌：Merck Millipore

规格：

目录价：￥4095.00

市场价格：￥3480.75

会员价格：￥3276.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Beta-parvin Antibody, clone 11A5 | MAB2620 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 41 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to human Beta-parvin. View All» Clone: 11A5 View All» Isotype: IgG2aκ View All» Background Information: Beta-parvin, also known as affixin, is a focal adhesion protein belonging to a family of ILK-binding proteins that contain tandem calponin homolog domains. Along with Alpha-parvin, Beta-parvin is one of the most widely researched and characterized members of this family. These two proteins interact with the ILK kinase domain in a way that is mutually exclusive and regulates both the activity of the kinase and actin cytoskeleton adhesion. Studies have shown Beta-parvin to be downregulated within human breast cancer cells, and that its expression may influence the progression of breast cancer (Johnstone, 2008). Additional research indicates a critical role for Beta-parvin in the regulation of cardiac contractility when it is in complex with ILK (Hannigan, 2007). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution detected Beta-parvin in NIH/3T3 and HeLa cells. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Beta-parvin in 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9HBI1 View All» Entrez Gene Number: NP_037459.2 View All» Gene Symbol:

• PARVB

• CGI-56
  View All» Alternate Names:
  • parvin beta

  • parvin-beta

  • affixin
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: Members of the parvin family, including PARVB, are actin-binding proteins associated with focal contacts.[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.SUBUNIT STRUCTURE: Interacts with DYSF. Interacts with integrin-linked protein kinase and actin. SUBCELLULAR LOCATION: Cell junction › focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Note: Constituent of focal adhesions.TISSUE SPECIFICITY: Expressed predominantly in heart and skeletal muscle. SEQUENCE SIMILARITIES: family.Contains 2 CH (calponin-homology) domains.SEQUENCE CAUTION: 34051.1 differs from that shown. Reason: Frameshift at positions 4, 14, 48, 58, 155, 162, 171, 327, 331 and 344. View All» Product Name: Anti-Beta-parvin, clone 11A5 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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