货号：MAB2011

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mucin MUC5AC Antibody, clone CLH2 | MAB2011 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Antibody MAB2011 is specific for the MUC5AC tandem repeat of human mucin. No cross reactivity with other peptides from MUC2, 3, 6, or 7. Immunoreactivity of MAB2011 has been detected in the following normal human epithelial tissues: bronchus, endocervix, stomach, and gallbladder. The predominant staining pattern in normal tissues is perinuclear. Antibody reactivity has been observed in foveolar and mucopeptic neck cells of normal gastric mucosa. The expression of MUC5AC has been frequently observed in gastric carcinomas and may be used as a marker of gastric differentiation. The CLH2 antibody shows a weak reactivity with a high molecular weight smear characteristic of mucin from native mucin extract from normal gastric mucosa and from gastric diffuse carcinoma . The antibody was generated by immunizing mice with a synthetic tandem repeat peptide The antibody recognizes the sequence TTSTTSAP within the tandem repeat of MUC5AC (1). It further recognizes glycosylated as well as unglycosylated MUC5AC. View All» Immunogen: Directed against a synthetic peptide of the MUC5AC tandem repeat. View All» Clone: CLH2 View All» Isotype: IgG1 View All» Background Information: Mucins are high molecular weight glycoproteins that are heavily glycosylated with oligosaccharide side chains linked O-glycosidically to the protein backbone. At least nine mucin genes have been identified to date. The pattern of tissue and cell-specific expression of these mucin genes suggests a distinct role for each member of the diverse mucin family. In epithelial cancers, many of the phenotypic markers for pre-malignant and malignant cells have been found on the carbohydrate and peptide moieties of mucin glycoproteins. Deregulation of tissue and cell-specific expression of mucin genes has also been described in epithelial cancers. At present, the role of mucin glyoproteins in various states of epithelial cell carcinogenesis, including the pre-neoplastic state and metastasis, is under investigation. View All» Species Reactivity: Human View All» Application Notes: Western blot:Clone CLH2 shows a weak reactivity with a high molecular weight smear characteristic of mucin from a native mucin extract from normal gastric mucosa and from gastric diffuse carcinoma. Typical dilution is 1:100. Immunocytochemistry Immunohistochemistry. Effective on frozen and paraffin sections at 1:1000-1:2000 dilution. ELISA Immunoprecipitation Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid at 1 mg/mL in 0.02M phosphate buffer, 0.25 M sodium chloride, 0.1% sodium azide, pH 7.6. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q6W4X9 View All» Entrez Gene Number: NM_005961.2 View All» Gene Symbol: MUC6 View All» Alternate Names: Gastric Mucin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• ELISA

• Immunoprecipitation

• Western Blotting

• Immunocytochemistry

• Immunohistochemistry (Paraffin)
  View All» UniProt Summary: FUNCTION: SwissProt: Q6W4X9 # May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.SIZE: 2392 amino acids; 252165 Da SUBUNIT: Multimer; disulfide-linked.SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.DEVELOPMENTAL STAGE: Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.PTM: O-glycosylated.SIMILARITY: SwissProt: Q6W4X9 ## Contains 1 CTCK (C-terminal cystine knot-like) domain. & Contains 1 TIL (trypsin inhibitory-like) domain. & Contains 3 VWFD domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Mucin MUC5AC Antibody, clone CLH2 | MAB2011 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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