货号：07-2068

品牌：Merck Millipore

规格：EA

目录价：￥3550.00

市场价格：￥3017.50

会员价格：￥2840.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PRDM2 (RIZ1) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PRDM2. View All» Molecular Weight: ~189 kDa View All» Epitope: C-terminus View All» Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding the C-terminal region of human PRDM2. View All» Background Information: PRDM2, also known as RIZ1, is a nuclear protein containing 8 zinc finger motifs. It contains an RB-binding motif that is related to that of the adenovirus E1A oncoprotein; RIZ also shares an antigenic epitope with the C- terminus of E1A. It is expressed in human retinoblastoma cells and at low levels in all other human cell lines examined. RIZ1 is a tumor suppressor gene, and RIZ1 inactivation is commonly found in many types of human cancers. RIZ1 inactivation most frequently occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, or missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Not tested in other species. View All» Application Notes: ELISA:This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000). View All» Quality Assurance: Immunohistochemistry:1:100 dilution of this antibody detected PRDM2 in formalin-fixed, paraffin-embedded human malignant melanoma tissue. View All» Purification Method: Protein G chromatography View All» Presentation: Purified rabbit polyclonal in buffer containing 0.09% NaN3. View All» Storage Conditions: Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q13029 View All» Entrez Gene Number: NM_0158662 View All» Gene Symbol:

• RIZ

• RIZ1

• RIZ2

• EC 2.1.1.43

• HUMHOXY1

• KMT8

• MTB-ZF

• OTTHUMP00000009642

• OTTHUMP00000009687
  View All» Alternate Names:
  • GATA-3 binding protein G3B

  • GATA-3-binding protein G3B

  • Lysine N-methyltransferase 8

  • MTE-binding protein

  • PR domain containing 2, with ZNF domain

  • PR domain-containing protein 2

  • Retinoblastoma protein-interacting zinc finger protein

  • Zinc finger protein RIZ

  • retinoblastoma protein-binding zinc finger protein

  • zinc-finger DNA-binding protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • ELISA
      View All» UniProt Summary: FUNCTION: S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.SUBUNIT STRUCTURE:Binds to the retinoblastoma protein (RB). Interacts with GATA3. SUBCELLULAR LOCATION: Nucleus. Ref.6 Ref.1 TISSUE SPECIFICITY: Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.SEQUENCE SIMILARITY: Contains 8 C2H2-type zinc fingers.Contains 1 SET domain. View All» Product Name: Anti-PRDM2 (RIZ1) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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