货号：MAB1759

品牌：Merck Millipore

规格：1EA

目录价：￥3319.94

市场价格：￥2821.95

会员价格：￥2655.95

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD59 Antibody, clone 2/24 | MAB1759 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Product Overview: BIOCHEMISTRY: p I = 6.1 View All» Specificity: This antibody binds to a 17-25kD glycoprotein (Fletcher et al., 1990a,b) which is distributed on human cells and has a glycosyl-phosphatidylinositol (GPI) linkage to the plasma membrane(Hadam, 1989). It is identical to other CD59 monoclonals, MEM-43 and YTH 53.1, defined at the 4th International Conference on Human Leucocyte Differentiation Antigens(Davies et al., 1989; Stefanova et al., 1989). CD59 is an inhibitor of attack by autologous complement(Ojcius et al., 1990) possibly by limiting incorporation of C9 into the membrane complex(Rollins & Sims, 1990; Meri et al., 1990). GPI linked proteins such as CD59 are deficient on cells from patients with the acquired clonal disorder paroxysmal nocturnal haemoglobulinuria (PNH) in which the erythrocytes are susceptible to lysis by complement and leading to anemia(Rosse, 1990). Evidence suggests that CD59 may be the most important complement regulatory protein missing in PNH(Fletcher et al., 1990; Yamashina et al., 1990). Cell reactivity (Fletcher et al., 1990a,b; Hadam, 1989): The antibody reacts with all leucocytes, platelets, fibroblasts, erythrocytes and most cell lines. It is negative on U937 and Daudi cell lines. It is reduced on affected cells from patients with PNH with a distribution reflecting the clonal nature of the disease. View All» Immunogen: Human erythrocytes View All» Clone: 2/24 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: This monoclonal is useful in studies of complement and homologous restriction of complement action of the properties of GPI linked proteins and in the characterisation of cells from patients with PNH. SUGGESTED USAGE DILUTION 1. Flow cytometry and indirect immunofluorescence 1:25 Dilute with isotonic buffer. Use 50 μl of the appropriate dilution per 1x10E6 cells in 100 μl buffer. View All» Presentation: Purified from mouse ascitic fluid. The antibody is supplied in phosphate buffered saline, pH 7.4, containing 0.2% bovine serum albumin and 0.1% sodium azide. The characteristics of each lot are tested by electrophoresis and flow cytometry. View All» Storage Conditions: Store at 2 to 8°C, for up to 6 months. For prolonged periods, store below -20°C in undiluted aliquots. AVOID REPEATED FREEZE/THAW CYCLES. WARNING: The monoclonal reagent solution contains 0.1% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water. View All» UniProt Number: P13987 View All» Entrez Gene Number:

• NM_000611.4

• NM_203329.1

• NM_203330.1

• NM_203331.1
  View All» Gene Symbol:
  • CD59

  • MACIF

  • MIN2

  • MIN3

  • PROTECTIN

  • HRF-20

  • 16.3A5

  • MSK21

  • EJ16

  • HRF20

  • EL32

  • G344

  • MIC11

  • MIN1

  • Protectin

  • MAC-IP

  • MGC2354

  • EJ30

  • MIRL

  • p18-20
    View All» Alternate Names: Protectin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunofluorescence
      View All» UniProt Summary: FUNCTION: SwissProt: P13987 # Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.SIZE: 128 amino acids; 14177 Da SUBUNIT: Interacts with T-cell surface antigen CD2.SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.PTM: N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. & Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes.SIMILARITY: SwissProt: P13987 ## Contains 1 UPAR/Ly6 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-CD59 Antibody, clone 2/24 | MAB1759 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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