货号：05-1912

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PDK, clone 3H1.2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~49 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human PDK. View All» Clone: 3H1.2 View All» Isotype: IgMκ View All» Background Information: Pyruvate dehydrogenase kinase (PDK) is a mitochondrial enzyme important in metabolism that controls the pyruvate dehydrogenase complex and links glycolysis to the citric acid cycle. PDK is thought to regulate all aerobic oxidation of carbohydrates. Interestingly, inhibition of PDK disrupts glycolysis and increases mitochondrial respiration which causes a decrease in colorectal cancer cell proliferation, without effecting non-cancerous cells. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected PDK in PC12 cells. View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated by Western Blot in K562 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected PDK on 10 µg of K562 cell lysate. View All» Purification Method: Ion exchange View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15118 View All» Entrez Gene Number: NP_002601 View All» Gene Symbol:
  • PDK1

  • PDK
    View All» Alternate Names:
    • [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial

    • Pyruvate dehydrogenase kinase isoform 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. CATALYTIC ACTIVITY: ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.ENZYME REGULATION: Inhibited by AZD7545, dichloroacetate and radicicol. SUBCELLULAR LOCATION: Mitochondrion matrix. TISSUE SPECIFICTY: Expressed predominantly in the heart.SEQUENCE SIMILARITIES: Belongs to the PDK/BCKDK protein kinase family.Contains 1 histidine kinase domain. View All» Product Name: Anti-PDK, clone 3H1.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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