货号：MAB1275

品牌：Merck Millipore

规格：100Ug

目录价：￥3516.00

市场价格：￥2988.60

会员价格：￥2812.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HLA-ABC Common Antibody, clone 22.63.4 | MAB1275 View All» Replaces: MAB1280 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Product Overview: BIOCHEMISTRY: p I = 7.8 View All» Specificity: This antibody reacts with a common framework determinant of the 40-44kD protein of HLA-ABC Class I antigen. The antibody precipitates antigens of 40 - 44kD and 12kD (b2-microglobulin). Cell reactivity: The antibody reacts with all cells having HLA-ABC surface antigen. Erythrocytes and K562 and DAUDI are negative. View All» Immunogen: Nalm-6 cell line View All» Clone: 22.63.4 View All» Isotype: IgG2b View All» Species Reactivity: Human View All» Application Notes: This antibody is suitable for indirect immunofluorescence analysis by flow cytometry and is an excellent positive control. It is suitable for cryostat sections but not for routine formalin fixed paraffin sections. If the tissue is prepared at 4°C and fixed in PLP (Periodate-Lysine-Paraformaldehyde) before paraffin embedding, the antigen can be conserved (Hancock, 1982). SUGGESTED USAGE DILUTION 1. Flow cytometry and indirect immunofluorescence 1:15 - 1:60 Dilute with isotonic buffer. Use 50 μl of diluted antibody per 1 x 10E6 peripheral blood mononuclear cells (PBMC) in 100 μl buffer. 2. Indirect immunoperoxidase staining - the final dilution will depend on the assay conditions and detection system employed. However, a dilution of at least 1:15 will be applicable to most commonly used systems. View All» Presentation: Purified from mouse ascitic fluid. The antibody is supplied in phosphate buffered saline, pH 7.4 containing 0.1% sodium azide, diluted 50% v/v with glycerol. The characteristics of each lot are tested by electrophoresis and flow cytometry. View All» Storage Conditions: Store at 2 to 8°C, for up to 6 months. For prolonged periods, store at -15 to -20°C in undiluted aliquots. At this temperature the glycerol solution will not freeze. WARNING: The monoclonal reagent solution contains 0.05% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water. View All» UniProt Number:

• P16189

• P10321

• P30498
  View All» Entrez Gene Number: NM_002116.5 View All» Gene Symbol:
  • HLA-A

  • A-1

  • Aw-34

  • A-10

  • Aw-74

  • Aw-19

  • A-28

  • Aw-80

  • Aw-69

  • Aw-36

  • HLAA

  • Aw-66

  • Aw-43

  • A-9

  • Aw-68

  • Aw-24

  • Aw-33
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. View All» UniProt Summary: FUNCTION: SwissProt: P30498 # Involved in the presentation of foreign antigens to the immune system.| Q31612 # Involved in the presentation of foreign antigens to the immune system.| P30488 # Involved in the presentation of foreign antigens to the immune system.| P03989 # Involved in the presentation of foreign antigens to the immune system.| P30493 # Involved in the presentation of foreign antigens to the immune system.| P30460 # Involved in the presentation of foreign antigens to the immune system.| P30484 # Involved in the presentation of foreign antigens to the immune system.| P01889 # Involved in the presentation of foreign antigens to the immune system.| P30485 # Involved in the presentation of foreign antigens to the immune system.| Q29940 # Involved in the presentation of foreign antigens to the immune system.| P30483 # Involved in the presentation of foreign antigens to the immune system.| P30495 # Involved in the presentation of foreign antigens to the immune system.| P30492 # Involved in the presentation of foreign antigens to the immune system.| P18465 # Involved in the presentation of foreign antigens to the immune system.| P30487 # Involved in the presentation of foreign antigens to the immune system.| P30480 # Involved in the presentation of foreign antigens to the immune system.| P30491 # Involved in the presentation of foreign antigens to the immune system.| Q95365 # Involved in the presentation of foreign antigens to the immune system.| Q29836 # Involved in the presentation of foreign antigens to the immune system.| Q29718 # Involved in the presentation of foreign antigens to the immune system.| P30475 # Involved in the presentation of foreign antigens to the immune system.| P18464 # Involved in the presentation of foreign antigens to the immune system.| P30479 # Involved in the presentation of foreign antigens to the immune system.| P30490 # Involved in the presentation of foreign antigens to the immune system.| P10319 # Involved in the presentation of foreign antigens to the immune system.| P30466 # Involved in the presentation of foreign antigens to the immune system.| P30461 # Involved in the presentation of foreign antigens to the immune system.| P18463 # Involved in the presentation of foreign antigens to the immune system.| Q04826 # Involved in the presentation of foreign antigens to the immune system.| P30481 # Involved in the presentation of foreign antigens to the immune system.| P30685 # Involved in the presentation of foreign antigens to the immune system.| P30462 # Involved in the presentation of foreign antigens to the immune system.| Q31610 # Involved in the presentation of foreign antigens to the immune system.| P30486 # Involved in the presentation of foreign antigens to the immune system.| P30464 # Involved in the presentation of foreign antigens to the immune system.SIZE: 362 amino acids; 40478 Da SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DOMAIN: SwissProt: P30498 PTM: Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).DISEASE: "SwissProt: P03989 # HLA-B27 is associated with the development of ankylosing spondylitis (AS) [MIM:106300]. AS is a chronic inflammatory rheumatic disease that mainly affects the axial skeleton and is considered the prototype of seronegative spondyloarthropathies (SNSA), which include reactive arthritis (e.g., Reiter's syndrome), psoritic spondylitis, and other spondyloarthropathies (SpA). In the Greek Cypriot population, a restricted number of HLA-B27 subtypes are associated with AS and other B27-related diseases and an elevated frequency of the B*2702 allele in the AS patients is identified. The allele B*2707 seems to have a protective role in this population because it was found only in the healthy controls.| P18464 # HLA-B51 is associated with Behcet disease but it is not certain whether HLA-B51 itself or a closely linked gene is responsible for susceptibility. About 20% of healthy individuals of various ethnic origin carries the HLA-B 51 locus, compared with 50 to 80% of patients. Behcet disease is a systemic disorder of recurrent acute inflammation characterized by 4 major symptoms: oral aphthous ulcers, skin lesions, ocular symptoms and genital ulcerations. Occasionally, inflammation in tissues and organs throughout the body can occur, including the gastrointestinal tract, central nervous system, vascular system, lungs, and kidneys. The etiology of Behcet disease is unclear.| P30464 # Involved in susceptibility to Stevens-Johnson syndrome [MIM:608579]. This is a life-threatening reaction of the skin to particular types of medication. It is characterized by high fever, malaise and blistering exanthema. The more severe form of the disease is referred to as toxic epidermal necrolysis."SIMILARITY: SwissProt: P30498 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | Q31612 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30488 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P03989 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30493 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30460 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30484 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P01889 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30485 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | Q29940 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30483 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30495 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30492 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P18465 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30487 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30480 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30491 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | Q95365 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | Q29836 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | Q29718 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30475 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P18464 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30479 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30490 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P10319 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30466 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30461 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P18463 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | Q04826 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30481 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30685 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30462 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | Q31610 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30486 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. | P30464 ## Belongs to the MHC class I family. & Contains 1 Ig-like C1-type (immunoglobulin-like) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-HLA-ABC Common Antibody, clone 22.63.4 | MAB1275 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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