货号：MAB10750

品牌：Merck Millipore

规格：

目录价：￥4497.00

市场价格：￥3822.45

会员价格：￥3597.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LIMK1 Antibody, clone 40/00-1B11-1-1 | MAB10750 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes LIMK1. View All» Molecular Weight: ~ 73 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to a region of mouse LIMK1. View All» Clone: 40/00-1B11-1-1 View All» Isotype: IgG2aκ View All» Background Information: LIM Kinase 1 (LIMK1) is a protein kinase that plays an important role in cellular functions like cell motility and growth cone actin dynamics. LIMK1 contains one PDZ domain and two LIM domains which mediate protein to protein inteactions. It is widely expressed in the adult and fetal nervous system with the highest levels being found in the cerebral cortex. Mutations in LIMK1 have been associated with cardiovascular and musculo-skeletal abnormalities. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human. Predicted to react with mouse based on 100% sequence homology. View All» Control: PC3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC3 cell lysate.Western Blot Analysis: 0.5 µg/ml of this antibody detected LIMK1 on 10 µg of PC3 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P53668 View All» Entrez Gene Number: NM_010717.2 View All» Gene Symbol:
  • Limk

  • Limk1
    View All» Alternate Names:
    • LIM domain kinase 1

    • LIM motif-containing protein kinase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunocytochemistry

      • Immunohistochemistry
        View All» Entrez Gene Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. View All» UniProt Summary: FUNCTION: Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.SUBUNIT STURCTURE: Self-associates. Binds ROCK1 By similarity. The LIM domain interacts with the cytoplasmic domain of NRG1. Interacts with NISCH and SSH1.SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highest expression in the nervous system, particularly in the spinal cord and the cranial nerve and dorsal root ganglia.PTM: Autophosphorylated By similarity.Phosphorylated on serine and/or threonine residues by ROCK1. May be dephosphorylated and inactivated by SSH1. INVOLVEMENT IN DISEASE: Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Contains 2 LIM zinc-binding domains.Contains 1 PDZ (DHR) domain.Contains 1 protein kinase domain. View All» Product Name: Anti-LIMK1, clone 40/00-1B11-1-1 View All» Concentration: 0.7 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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