货号：552723

品牌：BD Pharmingen

规格：1EA

目录价：￥3220.00

市场价格：￥2028.60

会员价格：￥1771.00

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Catalog Number

552723

Brand

BD Pharmingen™

Name

CD138

Alias

Syndecan-1

Size

100Tests

RegulatoryStatus

RUO

Clone

MI15

Format

FITC

Isotype

IgG₁, κ

W.S. No

VI BP100, B005

W.B. Positive Control

none

Reactivity

QC Testing : Human

Applications

Flow cytometry

- Routinely Tested

Clone - Description

CD138 recognizes syndecan-1, a member of the syndecan family of transmembrane heparin sulfate proteoglycans whose main functions are to modulate ligand-dependent activation of primary signaling receptors at the cell surface. Syndecan-1 exhibits molecular polymorphism; its core protein is a singl-chain molecule of 70 to 75 kilodaltons (kd), and its isoforms vary in molecular weight up to approximately 400 kd.CD138 specifically identifies human plasma cells. It strongly reacts with all multiple myeloma cell lines, with malignant plasma cells on Reed-Sternberg Cells of classic Hodgkin?s disease (HD), both membrane and cytoplasmic; and on tumor cells or primary effusion lymphoma (PEL). The CD138 antigen appears during activation and differentiation of B cells and is specific for the terminally differentiated B cell. B-CLL cells are positive for syndecan-1. The CD138 antigen is consistently not expressed on putative tumor cells of nodular lymphocyte predominance (LP) subtype of HD, and not detected in B-cell malignancies of subsets of NHL, chronic lymphocytic leukemia, and hairy-cell leukemia. Mantle cell lymphoma is negative for syndecan-1, and there is no reaction with peripheral blood, bone marrow, or tonsil cells.