Nuvia cPrime Mixed-Mode Media

Fig. 1. Mixed-mode ligands for Nuvia cPrime (top) and aPrime 4A (bottom) Resins.

Providing highly reliable recovery across a wide range of salt concentrations and pH at high flow rates, Nuvia cPrime Media is particularly suitable for commercial manufacturing settings. Designed with a mixed-mode ligand that combines hydrophobic and cation exchange (CEX) properties (Figure 1), Nuvia cPrime Media has a large design space for binding and elution, allowing for the development of highly robust methods.

Nuvia aPrime 4A Mixed-Mode Media

Optimized to maximize mass transfer of biotherapeutics for optimal purity and recovery at high flow rates, Nuvia aPrime 4A Media is designed with both hydrophobic and anion exchange (AEX) chromatographic capabilities. Nuvia aPrime 4A Media is built upon the same rigid macroporous highly crosslinked polymer base matrix as Nuvia cPrime Media and features a strong AEX ligand together with a hydrophobic aromatic side chain (Figure 1). Example mAb purification workflows demonstrating the utility of Nuvia aPrime 4A Media are given in Figure 2.