GK121 ScienCell 人PD-1/PD-L1检查点途径qPCR检测试剂盒，GeneQuery™ Human PD-1/PD-L1 Checkpoint Pathway qPCR Array Kit

ScienCell 研究实验室（ScienCell）是一家生物技术公司，其使命是实验和治疗用细胞和细胞科研金山平台现货促销授权一级代理，咨询微信：jinshanbio 金山禾斗石开平台总代理的研究和发展。 ScienCell为研究界提供各种高质量的正常的人类和动物细胞，细胞培养基和试剂，培养基添加因子，细胞来源的RNA，cDNA和蛋白质。ScienCell的科学家们以改善生活质量，实现细胞的能力，打击人类退化性疾病为目的研究和开发各种细胞治疗策略。ScienCell总部设在美国加利福尼亚州圣地亚哥，公司成立于1999年。

北京诺博莱德作为ScienCell品牌的特约代理商，为客户提供，正规进口，保证原装正品，货期稳定，折扣好的服务标准。

GK121 ScienCell人PD-1/PD-L1检查点途径qPCR检测试剂盒，GeneQuery™ Human PD-1/PD-L1 Checkpoint Pathway qPCR Array Kit，产品简介：

产品品牌： ScienCell

产品货号：GK121

产品名称：GK121 ScienCell人PD-1/PD-L1检查点途径qPCR检测试剂盒，GeneQuery™ Human PD-1/PD-L1 Checkpoint Pathway qPCR Array Kit

产品规格：One 96-well plate, one 20ul reaction per well

GK121 ScienCell人PD-1/PD-L1检查点途径qPCR检测试剂盒，GeneQuery™ Human PD-1/PD-L1 Checkpoint Pathway qPCR Array Kit， 产品说明：

ScienCell 的 GeneQuery™ 人 PD-1/PD-L1 检查点通路 qPCR 阵列试剂盒 （GQH-PDI） 旨在促进参与人类 PD-1/PD-L1 检查点通路的 88 个关键基因的基因表达谱分析，并帮助识别癌症免疫治疗的潜在预后生物标志物。 PD-1/PD-L1检查点通路在维持T细胞稳定性以及介导T效应细胞增殖和功能的抑制信号方面起重要作用。PD-1/PD-L1免疫检查点阻断可增强T细胞对肿瘤和病毒病原体的免疫力。下面显示了如何根据其功能对基因进行分组的简要示例：

共刺激/抑制受体：PDCD1 （PD-1）、CD28、CD27、CD276、ICOS、TNFRSF18、TNFRSF4、TNFRSF9

共刺激/抑制途径：CD274 （PD-L1）， PDCD1LG2 （PD-L2）， CD4， LCK， CD2， CD247， CSK， PTPN11， PTPN2， PTPN6， NCOR2

PD-L1 诱导： IFNG， IL15， IL17A， IL2， IL21， IL7， MAPK1， NRP1， STAT3

T 细胞受体信号传导：AKT1、CD3、CTLA4、CD8、GSK3B、JUN、NFKB1、PDPK1

T细胞功能调节：BATF，FOXO1，KRAS，MAPK8，MTOR，NFATC1，PI3Ks，SKP2，TLR9

B细胞功能调节：CD80，CD86，POU2F2

促炎分子：脑脊液2、IL4、IL10、IRF6、TNF、VEGFA

其他免疫检查点基因：HAVCR2，HNF1A，LAG3，TIGIT

注意：所有基因名称都遵循人类基因组组织基因命名委员会（HGNC）的guanfang符号。

ScienCell's GeneQuery™ Human PD-1/PD-L1 Checkpoint Pathway qPCR Array Kit (GQH-PDI) is designed to facilitate gene expression profiling of 88 key genes involved in human PD-1/PD-L1 checkpoint pathway, and to help identifying potential prognostic biomarkers for cancer immunotherapy. PD-1/PD-L1 checkpoint pathway plays an important role in the maintenance of T cell stability, as well as mediating inhibitory signals for proliferation and function of T effector cells. PD-1/PD-L1 immune checkpoint blockade has resulted in enhancement of T cell immunity against tumors and viral pathogens. Brief examples of how genes may be grouped according to their functions are shown below:

· Co-stimulatory/inhibitory receptors:PDCD1 (PD-1), CD28, CD27, CD276, ICOS, TNFRSF18, TNFRSF4, TNFRSF9

· Co-stimulatory/inhibitory pathway:CD274 (PD-L1), PDCD1LG2 (PD-L2), CD4, LCK, CD2, CD247, CSK, PTPN11, PTPN2, PTPN6, NCOR2

· PD-L1 induction:IFNG, IL15, IL17A, IL2, IL21, IL7, MAPK1, NRP1, STAT3

· T cell receptor signaling:AKT1, CD3, CTLA4, CD8, GSK3B, JUN, NFKB1, PDPK1

· T cell function regulation:BATF, FOXO1, KRAS, MAPK8, MTOR, NFATC1, PI3Ks, SKP2, TLR9

· B cell function regulation:CD80, CD86, POU2F2

· Proinflammatory molecules:CSF2, IL4, IL10, IRF6, TNF, VEGFA

· Additional immune checkpoint genes:HAVCR2, HNF1A, LAG3, TIGIT

Note:all gene names follow their official symbols by the Human Genome Organization Gene Nomenclature Committee (HGNC).

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