GK124 ScienCell 人类转录因子qPCR检测试剂盒，Human Transcription Factors qPCR Array Kit

ScienCell 研究实验室（ScienCell）是一家生物技术公司，其使命是实验和治疗用细胞和细胞科研金山平台现货促销授权一级代理，咨询微信：jinshanbio 金山禾斗石开平台总代理的研究和发展。 ScienCell为研究界提供各种高质量的正常的人类和动物细胞，细胞培养基和试剂，培养基添加因子，细胞来源的RNA，cDNA和蛋白质。ScienCell的科学家们以改善生活质量，实现细胞的能力，打击人类退化性疾病为目的研究和开发各种细胞治疗策略。ScienCell总部设在美国加利福尼亚州圣地亚哥，公司成立于1999年。

北京诺博莱德作为ScienCell品牌的特约代理商，为客户提供，正规进口，保证原装正品，货期稳定，折扣好的服务标准。

GK124 ScienCell人类转录因子qPCR检测试剂盒，Human Transcription Factors qPCR Array Kit，产品简介：

产品品牌： ScienCell

产品货号：GK124

产品名称：GK124 ScienCell人类转录因子qPCR检测试剂盒，Human Transcription Factors qPCR Array Kit

产品规格：One 96-well plate, one 20ul reaction per well

GK124 ScienCell人类转录因子qPCR检测试剂盒，Human Transcription Factors qPCR Array Kit， 产品说明：

ScienCell的GeneQuery™人类转录因子qPCR阵列试剂盒（GQH-TRF）调查了88种转录因子的小组。转录因子是通过结合称为增强子或沉默剂的基因组特定区域来调节靶基因转录水平的蛋白质。转录因子的错误调节可导致信号转导畸变和各种疾病，包括自身免疫、神经系统疾病、糖尿病、心血管疾病和癌症。下面显示了如何根据其功能对基因进行分组的简要示例：

干细胞相关：NANOG，POU5F1，SOX2，EGR1，FOXD3，FOXO1，KLF4，MEF2B，PAX6，SOX18

癌症干细胞相关：NANOG，POU5F1，SOX2，AR，FOXO3，MYC，NKX3-1，SNAI1，SOX9，TFAP2A，TP53，TWIST1

氧化应激相关：ARNT，ETS1 / 2，IRF1，JUN，NFAT5，NFKB1，NFYA，SMAD1，SRF，STAT3

神经保护功能相关： CREB1， ESR1， FOXA1， GATA1/2/3， NFE2L2， NR4A2， PPARA， SP1， TBX3

生长因子介导的信号通路：CREBBP，ELK1，FOS，HIF1A，ID1，NFAT5，NFATs，STAT1 / 3 / 5A

Wnt信号通路：CEBPA，CEBPB，GBX2，HNF4A，LEF1，MITF，OLIG1，PITX2，SMAD4，SOX2

MAPK信号通路： ATF2/4， ELK1， FOX， JUN， MAX， MEF2A/C， NFKB1， SP1， STAT1/3

B / T细胞受体信号通路：E2F1，ELK1，FOS，GATA3，JUN，MYB，NFAT，RUNX1，STAT6

癌基因和肿瘤抑制因子：ABL1，BRCA1，CDKN2A，JUNB，MYCN，NF1，RARA，RB1，TGFB1，TNF

注意：所有基因名称都遵循人类基因组组织基因命名委员会（HGNC）的guanfang符号。

GeneQuery™ qPCR 芯片试剂盒采用 96 孔板格式的 qPCR 就绪，每个孔包含一个引物组，可以特异性识别并有效扩增靶基因的 cDNA。精心设计的引物确保：（i）qPCR分析中的最佳退火温度为65°C（含2 mM Mg2+，不含DMSO）;（ii）除非另有说明，否则引物组可识别靶基因的所有已知转录本变体;（iii）只有一个基因被扩增。每个引物组都已通过qPCR和熔解曲线分析和凝胶电泳进行了验证。

ScienCell's GeneQuery™ Human Transcription Factors qPCR Array Kit (GQH-TRF) surveys a panel of 88 transcription factors. Transcription factors are proteins that can regulate target gene transcription level by binding to specific regions of genome known as enhancers or silencers. Misregulation of transcription factors can lead to aberrations in signaling transduction and a variety of disorders including autoimmunity, neurological disorders, diabetes, cardiovascular disease and cancer. Brief examples of how genes may be grouped according to their functions are shown below:

· Stem cell-related:NANOG, POU5F1, SOX2, EGR1, FOXD3, FOXO1, KLF4, MEF2B, PAX6, SOX18

· Cancer stem cell-related:NANOG, POU5F1, SOX2, AR, FOXO3, MYC, NKX3-1, SNAI1, SOX9, TFAP2A, TP53, TWIST1

· Oxidative stress-related:ARNT, ETS1/2, IRF1, JUN, NFAT5, NFKB1, NFYA, SMAD1, SRF, STAT3

· Neuroprotective function-related:CREB1, ESR1, FOXA1, GATA1/2/3, NFE2L2, NR4A2, PPARA, SP1, TBX3

· Growth factor-mediatedsignaling pathways:CREBBP, ELK1, FOS, HIF1A, ID1, NFAT5, NFATs, STAT1/3/5A

· Wnt signaling pathway:CEBPA, CEBPB, GBX2, HNF4A, LEF1, MITF, OLIG1, PITX2, SMAD4, SOX2

· MAPK signaling pathway:ATF2/4, ELK1, FOX, JUN, MAX, MEF2A/C, NFKB1, SP1, STAT1/3

· B/T-cell receptor signaling pathways:E2F1, ELK1, FOS, GATA3, JUN, MYB, NFATs, RUNX1, STAT6

· Oncogenes & tumor suppressors:ABL1, BRCA1, CDKN2A, JUNB, MYCN, NF1, RARA, RB1, TGFB1, TNF

Note:all gene names follow their official symbols by the Human Genome Organization Gene Nomenclature Committee (HGNC).

GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg2+, and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.

基因查询™人类转录因子qPCR阵列板布局 *（8 个粗体和斜体控件）

注意：所有基因名称都遵循HGNC的guanfang符号

提示：基因选择可能会根据新的研究和开发进行更新

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