产品英文名称：Anti-EpCAM

产品中文名称：抗-EpCAM

BD 抗-EpCAM Anti-EpCAM APC (RUO) 347200产品英文介绍：

Catalog Number 347200

Name CD326

Alias EpCAM

Size 100 Tests

Regulatory Status RUO (GMP)

List Price Inquire

Related Molecules EPCAM

Clone EBA-1

Format APC

Isotype IgG1, λ

W.S. No none

W.B. Positive Control none

Molecular Weight none

Reactivity QC Testing : Human

Applications Routinely Tested: Flow cytometry

Clone – Description

Anti-EpCAM is directed against a human epithelial adhesion molecule (EpCAM) that has been identified as a 40-kilodalton (kd) protein in Western Blotting. This antigen is also known as epithelial surface antigen (ESA) and epithelial glycoprotein 2 (EGP-2).The epithelial cells present in non-squamous epithelia and tumors derived from such cells show EpCAM expression. The normal epithelial cells reactive with anti-EpCAM antibodies are those present in the (lower) respiratory tract; the (lower) gastrointestinal tract; tubules in the kidney; the surface epithelium of the ovary; the exocrine and endocrine pancreas; secondary germ cells of telogenic hair follicles; and secretory tubules of sweat glands in the skin, whereas the epidermis is negative. In addition, all epithelial cells in the thyroid and epithelial cells in the thymus show EpCAM expression, while the outer cortex and Hassall’s corpuscles have low expression. In the liver, only the bile ducts appear to be positive with anti-EpCAM antibodies. Non-squamous–carcinoma cells have high EpCAM expression, whereas such expression can also occur in squamous carcinoma. Tumors arising from non-epithelial cells, such as lymphoma, mesothelioma, neuroblastoma, and melanoma, do not express EpCAM.

BD 抗-EpCAM Anti-EpCAM APC (RUO) 347200介绍：

抗EpCAM是针对人上皮粘附分子（EpCAM的）已被确定为蛋白质印迹一个40千道尔顿（KD）的蛋白质。这种抗原也被称为上皮表面抗原（ESA）和上皮糖蛋白-2（EGP-2）。存在于非鳞状上皮细胞和从这些细胞衍生的肿瘤的上皮细胞显示EpCAM的表达。正常上皮细胞与抗-EpCAM抗体的反应性是指那些存在于（低级）呼吸道;的（低级）胃肠道;小管在肾;卵巢表面上皮;外分泌和内分泌胰腺;的调聚毛囊二次生殖细胞;和在皮肤汗腺的分泌小管，而表皮是负的。此外，所有的上皮细胞在胸腺中的甲状腺细胞和上皮细胞显示EpCAM的表达，而所述外皮层和哈索尔的微粒具有低的表达。在肝脏中，只有胆管似乎与抗-EpCAM抗体阳性。非鳞状癌细胞具有高EpCAM的表达，而这种表达也可以发生在鳞状细胞癌。从非上皮细胞，如淋巴瘤，间皮瘤，神经母细胞瘤和黑色素瘤产生的肿瘤，不表达EpCAM。

BD 抗-EpCAM Anti-EpCAM APC (RUO) 347200使用注意事项：

WARNING

Reagents contain sodium azide. Sodium azide is harmful if swallowed. Keep out of reach of children.

Keep away from food, drink, and animal feedingstuff. Wear suitable protective clothing. If

swallowed, seek medical advice immediately and show this container or label. Contact with acids

liberates very toxic gas. Azide compounds should be flushed with large volumes of water during

disposal to avoid deposits in lead or copper plumbing where explosive conditions can develop.