产品英文名称：EZH2 phospho Thr345 antibody (pAb)

产品中文名称：EZH2抗体 磷酸化Thr345抗体（PAB）

Active Motif EZH2抗体 磷酸化Thr345抗体（PAB）产品简介：

Active Motif EZH2抗体 磷酸化Thr345抗体（PAB）产品英文描述：

Background: EZH2– (Enhancer of Zeste homolog 2, also designated Enx1) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27(Histone H3 Lys27 monomethylated, dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure.EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. Threonine 345 of mouse Ezh2 is phosphorylated in a cell cycle-dependent manner and may play a role in the interaction of Ezh2 with HOTAIR and the 59-RepA repeats of Xist. (see reference)

Immunogen:

This EZH2 phospho Thr345 antibody was raised against a peptide containing phosphothreonine 345 of mouse EZH2 (enhancer of zeste homolog 2 (Drosophila))

Buffer:

Purified IgG in PBS with 30% glycerol and 0.035% sodium azide.

Application Notes:

This EZH2 phospho Thr345 antibody has been validated for use in Western blotting. See references for more details.

References:

WB: Kaneko S, et al (2010) 24(23):2615-2620

Storage and Guarantee:

Antibodies in solution can be stored at -20°C for 2 years.

Avoid repeated freeze/thaw cycles and keep on ice when not in storage. This product is guaranteed for 6 months from date of arrival.