产品英文名称：EZH2 antibody (mAb)

产品中文名称：EZH2 抗体 (mAb))

Active Motif EZH2 抗体 antibody (mAb) 抑癌蛋白产品介绍：

Active Motif EZH2 抗体 antibody (mAb) 抑癌蛋白产品英文描述：

Background:

EZH2 – (Enhancer of Zeste homolog 2, also designated Enx1 and SETDB1) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27 (Histone H3 Lys27 monomethylated,dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. EZH2 associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems.Deregulation of EZH2 is linked to a variety of cancers.

Immunogen:

This EZH2 antibody was raised against a recombinant protein corresponding to amino acids 353-451 of human EZH2.

Buffer:

Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine,0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.

Application Notes:

This EZH2 antibody has been validated for use in chromatin IP (1-3 μg per ChIP), immunofluorescence and immunoprecipitation. See References for more information.

This antibody is not recommended for use in Western blotting.Use 39933 instead.

Storage and Guarantee:

Antibodies in solution can be stored at -20°C for 2 years.Avoid repeated freeze/thaw cycles and keep on ice when not in storage. This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.