产品英文名称：BMI-1 antibody (mAb)

产品中文名称：BMI-1 抗体 (mAb)

Active Motif抗体 BMI-1 抗体 (mAb)产品简介：

BMI-1 antibody (mAb) Background:

BMI-1 is a member of the Polycomb PRC1 complex that is recruited to transcriptionally repressed genes subsequent to histone H3 lysine 27 methylation in order to maintain repression. In the PRC1 complex, BMI-1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2, resulting in the ubiquitylation of histone H2A at lysine 119.

BMI-1 acts as an oncogene and cooperates with c-myc in the initiation of lymphoma. High levels of expression of BMI-1 are observed in metastatic melanoma, and BMI-1 has been implicated in several other cancers. BMI-1 is required for hematopoietic stem cell self renewal.

BMI-1 antibody (mAb) Immunogen:

This BMI-1 antibody was raised against a recombinant protein corresponding to full-length mouse BMI-1.

BMI-1 抗体 (mAb)缓冲液：

纯化IgG在70mMTris （pH8）中， 105 mM氯化钠， 31 mM的甘氨酸0.07mMEDTA ，30％甘油和0.035 ％叠氮化钠。叠氮化钠是剧毒的。

BMI-1 抗体 (mAb)应用说明：

这BMI -1抗体已经被证实在染色质的IP （芯片， 2-10微克每个片）的使用和免疫共沉淀（ 2-10微克每个IP ） 。详情请参阅参考资料。

BMI-1 抗体 (mAb)存储和保证：

在溶液中的抗体可被储存在-20 ℃下2 年进行.避免重复冷冻/解冻循环并保持在冰上当没有存储的时候。本产品保证6个月自收到之日起。