金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Mineralocorticoid R/NR3C2 Long Name: Mineralocorticoid Receptor Aliases: MLR; NR3C2 Entrez Gene IDs: 4306 (Human) Background: Mineralocorticoid Receptor

Mineralocorticoid Receptor (MR) is a member of the nuclear hormone receptor family. Upon binding of ligand (aldosterone or corticosterone) mineralocorticoid receptors translocate to the nucleus and can form either homo or heterodimers. MR dimers bind to the mineralocorticoid response element (AGAACANNNTGTTCT) to regulate gene transcription. There are four known isoforms of MR.

Mineralocorticoid Receptos are expressed in the kidney, gut, brain, pituitary, hypothalamus and heart. MR plays a critical role in regulating electrolyte and fluid balance in the kidney, as well as having specific roles in the central nervous system. The protein is expressed as a 107 kDa nuclear form. MR and glucocorticoid receptors (GR) can cooperatively form heterodimers.