R&D Systems代理MAB756 Mouse Twisted Gastrulation (TSG) MAb (Clone 120024) (500 UG)

2025-06-27

货号:MAB756

品牌:R&D Systems

规格:500ug

目录价:¥5070.00

市场价格:¥4056.00

会员价格:¥4056.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Molecule Information: TSG Long Name: Twisted Gastrulation Homolog 1 [Drosophila] Aliases: TWSG1 Entrez Gene IDs: 57045 (Human); 65960 (Mouse) Background: TSG

    View TSG IHC images.Twisted gastrulation (TSG) is a secreted, cysteine-rich protein that plays a role in dorsal/ventral patterning in Drosophila and Xenopus by regulating BMP signaling. TSG was originally identified in Drosophila melanogaster and shown to be required for the differentiation of the dorsal amnioserosa cells. Studies of expression and function of Twisted Gastrulation have been performed in Drosophila and Xenopus. Xenopus TSG is expressed in the ventral regions of the embryo during gastrulation, mimicking the BMP-4 expression pattern. TSG is expressed in dorsal cells of the blastoderm embryo, where there are also high levels of activity of Dpp and Screw.

    Vertebrate TSGs were subsequently cloned in mouse, human, zebrafish and frog. TSG acts as an agonist for BMP signaling by modulating the inhibitory actions of the BMP antagonist, Chordin/Sog, and the cleavage properties of the metalloprotease, xolloid/tolloid. The N-terminal domain of TSG can bind BMP protein directly in vitro and shows BMP antagonist activity.

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