金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Hormone-sensitive Lipase/HSL Aliases: HSL; LHS; LIPE Entrez Gene IDs: 3991 (Human); 16890 (Mouse); 25330 (Rat) Background: Hormone-sensitive Lipase Hormone-sensitive Lipase (HSL), also called LIPE, is an 84 kDa phosphoprotein that is the rate-limiting enzyme in the catalytic breakdown of triglycerides. The human 775 amino acid (aa) form is active in adipose tissue and skeletal muscle. HSL translocates to triglyceride-metabolizing lipid droplets in response to epinephrine or contraction in skeletal muscle, but to the cytosol following insulin treatment of adipocytes. A 120 kDa isoform of human HSL with a 301 aa N-terminal extension is present only in the testes, localized to elongating spermatids and spermatozoa.