R&D Systems代理MAB7094 Human CEBP alpha MAb (Clone 692716) (100 UG)-试剂-金山科研平台

R&D Systems代理MAB7094 Human CEBP alpha MAb (Clone 692716) (100 UG)

2025-06-28

货号：MAB7094

品牌：R&D Systems

规格：100ug

目录价：￥3720.00

市场价格：￥2976.00

会员价格：￥2976.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: CEBP alpha Long Name: CCAAT/enhancer-Binding Protein alpha Aliases: C/EBP-alpha; CEBPA Entrez Gene IDs: 1050 (Human); 12606 (Mouse); 24252 (Rat) Background: CEBP alpha

View CEBP alpha IHC images. CCAAT-enhancer binding protein alpha (C/EBP alpha) is a widely expressed 42 kDa basic-leucine zipper transcription factor that forms functional homodimers and heterodimers with C/EBP beta and gamma. C/EBP alpha inhibits mitotic progression through multiple mechanisms and also promotes terminal differentiation of granulocytes and adipocytes. Its activity is regulated by SUMOylation and by phosphorylation at multiple serine residues. C/EBP alpha contains three TE transactivation domains (aa 1-69, aa 70-96, and aa 126-200) and one basic DNA binding motif and leucine zipper (aa 286-345). A 30 kDa isoform is generated by the use of an internal translation initiation site. The p30 isoform functions as a dominant negative factor by heterodimerizing with and inhibiting full length C/EBP alpha activity. Within aa 1-124, human C/EBP alpha shares 93% amino acid sequence identity with mouse and rat C/EBP alpha, respectively.

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