金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: DAPP1 Long Name: Dual Adaptor of Phosphotyrosine and 3-Phosphoinositides 1 Aliases: BAM32 Entrez Gene IDs: 27071 (Human); 26377 (Mouse); 362046 (Rat) Background: DAPP1 DAPP1, also known as Bam32, is a 32 kDa intracellular adaptor protein for tyrosine-phosphorylated proteins and 3-phosphoinositides. It is expressed in B cells, T cells, and mast cells and plays a role in signal transduction during the activation of these cell types. DAPP1 is also required for progression of germinal center reactions and the adhesion of B cells to T cells. It is recruited to the plasma membrane following PI 3-kinase activation. DAPP1 contains one SH2 (aa 34-129) and one PH (aa 164-259) domain. Alternate splicing generates an additional isoform with a 22 aa substitution at the C-terminus.