金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: LPP Long Name: Lipoma-Preferred Partner Entrez Gene IDs: 4026 (Human); 210126 (Mouse); 288010 (Rat) Background: LPP Human LIM domain-containing preferred translocation partner in lipoma (LPP) is an 80 kDa intracellular protein that contains an N-terminal Pro-rich region (aa 41-370) followed by three tandem LIM domains (aa 414-603). It localizes to focal adhesion plaques where it regulates junction assembly and cytoskeleton remodeling through interactions with alpha-Actinin, VASP, SCRIB, Supervillin, and Palladin. In the nucleus, LPP coactivates the transcription factor PEA3 and protects telomeres from DNA damage. LPP is a frequent target of chromosomal translocations with HMG-A2 in lipoma.